Studies investigating systemic inflammation in psoriasis use different serum markers and
report discrepant results. We set out to determine whether systemic inflammation is elevated …

Nowadays, it is well established a link between psoriasis and cardiovascular (CV) diseases.
A series of different overlapping mechanisms including inflammation, homeostasis …

Atopic dermatitis (AD) is the most common inflammatory skin disease, but treatment options
for moderate‐to‐severe disease are limited. Ustekinumab is an IL‐12/IL‐23p40 antagonist …

Context Ustekinumab and briakinumab, monoclonal antibodies to the shared p40 subunit of
interleukin (IL)-12 and IL-23, have shown efficacy in treating chronic plaque psoriasis (CPP) …

Concerns have been raised regarding an increased risk of major adverse cardiovascular
events (MACEs)(myocardial infarction, cerebrovascular accident or cardiovascular death) in …

Chronic itch is one of the most prominent clinical characteristics of diverse systematic
diseases. It is a devastating sensation in pathological diseases. Despite its importance …

Preclinical and clinical studies conducted in the mid-1990s reported strong association and
causality between the T-cell helper (TH) 1 inductor cytokine interleukin (IL)-12 and …

Abstract The interleukin (IL)-12/IL-23 pathway is one of many proposed mechanistic
pathways of intestinal inflammation. Earlier studies introduced IL-12 as a major cytokine in …

Introduction Several therapies for psoriasis have been described as triggers of biologic-
induced bullous pemphigoid (BIBP). The real incidence of BIBP in psoriatic patients is still …

Protein scaffolds can provide a promising alternative to antibodies for various biomedical
and biotechnological applications, including therapeutics. Here we describe the design and …