Drug delivery technologies have enabled the development of many pharmaceutical
products that improve patient health by enhancing the delivery of a therapeutic to its target …

Adipocytes are one of the primary stromal cells in many tissues, and they are considered to
play an active role in the tumor microenvironment. Cancer-associated adipocytes (CAAs) …

Triple negative breast cancer (TNBC) constitutes the most aggressive molecular subtype
among breast tumors. Despite progress on the underlying tumor biology, clinical outcomes …

The sonic hedgehog (Shh) signaling pathway is a major regulator of cell differentiation, cell
proliferation, and tissue polarity. Aberrant activation of the Shh pathway has been shown in …

Simple Summary Since the targeting of a single pro-angiogenic factor fails to improve
oncological disease outcome, significant efforts have been made to identify new pro …

Secondary hypertension refers to arterial hypertension due to an identifiable cause and
affects∼ 5–10% of the general hypertensive population. Because secondary forms are rare …

Engineered nanomaterials have been extensively employed as therapeutics for tumor
management. Meanwhile, the complex tumor niche along with multiple barriers at the …

Highlights•Tumor vessels form a physical barrier that hampers intratumoral T cell
trafficking.•Tumor endothelial cells can directly kill T cells or suppress their …

Mesenchymal stem cells (MSCs) are adult multipotent stem cells that are able to differentiate
into multiple specialized cell types including osteocytes, adipocytes, and chondrocytes …

Nanoparticles, especially liposomes, have gained prominence in the field of drug delivery
for the treatment of human diseases, particularly cancer; they provide several advantages …