[HTML][HTML] Purinergic signaling in the modulation of redox biology
Purinergic signaling is a cell communication pathway mediated by extracellular nucleotides
and nucleosides. Tri-and diphosphonucleotides are released in physiological and …
and nucleosides. Tri-and diphosphonucleotides are released in physiological and …
[HTML][HTML] Advances in therapies to treat neonatal hypoxic-ischemic encephalopathy
Neonatal hypoxic-ischemic encephalopathy (HIE) is a condition that results in brain damage
in newborns due to insufficient blood and oxygen supply during or after birth. HIE is a major …
in newborns due to insufficient blood and oxygen supply during or after birth. HIE is a major …
[HTML][HTML] Alteration of Gut Microbiome and Correlated Amino Acid Metabolism Contribute to Hyperuricemia and Th17-Driven Inflammation in Uox-KO Mice
S Song, Y Lou, Y Mao, X Wen, M Fan, Z He… - Frontiers in …, 2022 - frontiersin.org
Although gut dysbiosis had been demonstrated to be an important factor affecting
hyperuricemia (HUA) and gout, little is known for its potential mechanistic connections. In …
hyperuricemia (HUA) and gout, little is known for its potential mechanistic connections. In …
[HTML][HTML] Association between metabolic syndrome and uric acid: a systematic review and meta-analysis
E Raya-Cano, M Vaquero-Abellán, R Molina-Luque… - Scientific Reports, 2022 - nature.com
This systematic review and meta-analysis aim to provide the best evidence on the
association between metabolic syndrome (MetS) and uric acid (UA) by determining the size …
association between metabolic syndrome (MetS) and uric acid (UA) by determining the size …
[HTML][HTML] Oxidative stress and microRNAs in endothelial cells under metabolic disorders
Reactive oxygen species (ROS) are radical oxygen intermediates that serve as important
second messengers in signal transduction. However, when the accumulation of these …
second messengers in signal transduction. However, when the accumulation of these …
[HTML][HTML] Pathomechanisms of prenatally programmed adult diseases
Based on epidemiological observations Barker et al. put forward the hypothesis/concept that
an adverse intrauterine environment (involving an insufficient nutrient supply, chronic …
an adverse intrauterine environment (involving an insufficient nutrient supply, chronic …
Exposure to cadmium, lead, mercury, and arsenic and uric acid levels: results from NHANES 2007–2016
W Gao, L Tong, S Zhao, M Sun, J Fang, Y Xu… - Biological trace element …, 2023 - Springer
Mechanisms underlying abnormal uric acid (UA) levels from exposure to toxic
metals/metalloids have not been not fully elucidated, especially in the context of mixtures …
metals/metalloids have not been not fully elucidated, especially in the context of mixtures …
Chalcone derivatives as xanthine oxidase inhibitors: synthesis, binding mode investigation, biological evaluation, and ADMET prediction
C Yang, Y Liu, Y Tu, L Li, J Du, D Yu, P He, T Wang… - Bioorganic …, 2023 - Elsevier
Xanthine oxidase (XO) is a crucial target for the treatment of hyperuricemia and gout. A
series of derivatives based on natural 3, 4-dihydroxychalcone, obtained from Carthamus …
series of derivatives based on natural 3, 4-dihydroxychalcone, obtained from Carthamus …
Advances in experimental and clinical research of the gouty arthritis treatment with traditional Chinese medicine
H Liang, P Deng, YF Ma, Y Wu, ZH Ma… - Evidence‐Based …, 2021 - Wiley Online Library
Gouty arthritis (GA) is a multifactorial disease whose pathogenesis is utterly complex, and
the current clinical treatment methods cannot wholly prevent GA development. Western …
the current clinical treatment methods cannot wholly prevent GA development. Western …
Associations between composite dietary antioxidant index and gout: national health and nutrition examination survey 2007–2018
W Hu, Z Ye, T Li, Z Shi - Biological Research For Nursing, 2024 - journals.sagepub.com
Introduction: To explore the relationship between the composite dietary antioxidant index
(CDAI) and gout to provide support for preventing gout through dietary intervention …
(CDAI) and gout to provide support for preventing gout through dietary intervention …