[HTML][HTML] Purinergic signaling in the modulation of redox biology

LEB Savio, R Leite-Aguiar, VS Alves, R Coutinho-Silva… - Redox Biology, 2021 - Elsevier
Purinergic signaling is a cell communication pathway mediated by extracellular nucleotides
and nucleosides. Tri-and diphosphonucleotides are released in physiological and …

[HTML][HTML] Advances in therapies to treat neonatal hypoxic-ischemic encephalopathy

AK Ranjan, A Gulati - Journal of clinical medicine, 2023 - mdpi.com
Neonatal hypoxic-ischemic encephalopathy (HIE) is a condition that results in brain damage
in newborns due to insufficient blood and oxygen supply during or after birth. HIE is a major …

[HTML][HTML] Alteration of Gut Microbiome and Correlated Amino Acid Metabolism Contribute to Hyperuricemia and Th17-Driven Inflammation in Uox-KO Mice

S Song, Y Lou, Y Mao, X Wen, M Fan, Z He… - Frontiers in …, 2022 - frontiersin.org
Although gut dysbiosis had been demonstrated to be an important factor affecting
hyperuricemia (HUA) and gout, little is known for its potential mechanistic connections. In …

[HTML][HTML] Association between metabolic syndrome and uric acid: a systematic review and meta-analysis

E Raya-Cano, M Vaquero-Abellán, R Molina-Luque… - Scientific Reports, 2022 - nature.com
This systematic review and meta-analysis aim to provide the best evidence on the
association between metabolic syndrome (MetS) and uric acid (UA) by determining the size …

[HTML][HTML] Oxidative stress and microRNAs in endothelial cells under metabolic disorders

M Minjares, W Wu, JM Wang - Cells, 2023 - mdpi.com
Reactive oxygen species (ROS) are radical oxygen intermediates that serve as important
second messengers in signal transduction. However, when the accumulation of these …

[HTML][HTML] Pathomechanisms of prenatally programmed adult diseases

E Sulyok, B Farkas, J Bodis - Antioxidants, 2023 - mdpi.com
Based on epidemiological observations Barker et al. put forward the hypothesis/concept that
an adverse intrauterine environment (involving an insufficient nutrient supply, chronic …

Exposure to cadmium, lead, mercury, and arsenic and uric acid levels: results from NHANES 2007–2016

W Gao, L Tong, S Zhao, M Sun, J Fang, Y Xu… - Biological trace element …, 2023 - Springer
Mechanisms underlying abnormal uric acid (UA) levels from exposure to toxic
metals/metalloids have not been not fully elucidated, especially in the context of mixtures …

Chalcone derivatives as xanthine oxidase inhibitors: synthesis, binding mode investigation, biological evaluation, and ADMET prediction

C Yang, Y Liu, Y Tu, L Li, J Du, D Yu, P He, T Wang… - Bioorganic …, 2023 - Elsevier
Xanthine oxidase (XO) is a crucial target for the treatment of hyperuricemia and gout. A
series of derivatives based on natural 3, 4-dihydroxychalcone, obtained from Carthamus …

Advances in experimental and clinical research of the gouty arthritis treatment with traditional Chinese medicine

H Liang, P Deng, YF Ma, Y Wu, ZH Ma… - Evidence‐Based …, 2021 - Wiley Online Library
Gouty arthritis (GA) is a multifactorial disease whose pathogenesis is utterly complex, and
the current clinical treatment methods cannot wholly prevent GA development. Western …

Associations between composite dietary antioxidant index and gout: national health and nutrition examination survey 2007–2018

W Hu, Z Ye, T Li, Z Shi - Biological Research For Nursing, 2024 - journals.sagepub.com
Introduction: To explore the relationship between the composite dietary antioxidant index
(CDAI) and gout to provide support for preventing gout through dietary intervention …