Emerging mechanisms of cardiovascular protection for the omega-3 fatty acid eicosapentaenoic acid

RP Mason, P Libby, DL Bhatt - Arteriosclerosis, thrombosis, and …, 2020 - Am Heart Assoc
Patients with well-controlled LDL (low-density lipoprotein) levels still have residual
cardiovascular risk associated with elevated triglycerides. Epidemiological studies have …

Effects of dietary n–3 and n–6 polyunsaturated fatty acids in inflammation and cancerogenesis

KP Liput, A Lepczyński, M Ogłuszka… - International journal of …, 2021 - mdpi.com
The dietary recommendation encourages reducing saturated fatty acids (SFA) in diet and
replacing them with polyunsaturated fatty acids (PUFAs) n–3 (omega–3) and n–6 (omega …

Role of omega-3 fatty acids in cardiovascular disease: the debate continues

SCR Sherratt, P Libby, MJ Budoff, DL Bhatt… - Current atherosclerosis …, 2023 - Springer
Abstract Purpose of Review The omega-3 fatty acids (n3-FAs), eicosapentaenoic acid (EPA)
and docosahexaenoic acid (DHA), have recently undergone testing for their ability to reduce …

Blood omega-3 fatty acids and death from COVID-19: A pilot study

A Asher, NL Tintle, M Myers, L Lockshon… - … and Essential Fatty …, 2021 - Elsevier
Very-long chain omega-3 fatty acids (EPA and DHA) have anti-inflammatory properties that
may help reduce morbidity and mortality from COVID-19 infection. We conducted a pilot …

Role of DGAT enzymes in triacylglycerol metabolism

B Bhatt-Wessel, TW Jordan, JH Miller, L Peng - Archives of biochemistry …, 2018 - Elsevier
The esterification of a fatty acyl moiety to diacylglycerol to form triacylglycerol (TAG) is
catalysed by two diacylglycerol O-acyltransferases (DGATs) encoded by genes belonging to …

New insights into mechanisms of action for omega-3 fatty acids in atherothrombotic cardiovascular disease

R Preston Mason - Current atherosclerosis reports, 2019 - Springer
Abstract Purpose of Review Treatment of hypercholesterolemia with statins results in
significant reductions in cardiovascular risk; however, individuals with well-controlled low …

The Omega-3 Index and relative risk for coronary heart disease mortality: Estimation from 10 cohort studies

WS Harris, L Del Gobbo, NL Tintle - Atherosclerosis, 2017 - Elsevier
Background and aims A recent 19-cohort meta-analysis examined the relationships
between biomarkers of omega-3 fatty acids and risk for coronary heart disease (CHD). That …

Dietary fats and cardiometabolic disease: mechanisms and effects on risk factors and outcomes

JHY Wu, R Micha, D Mozaffarian - Nature Reviews Cardiology, 2019 - nature.com
The effect of dietary fats on cardiometabolic diseases, including cardiovascular diseases
and type 2 diabetes mellitus, has generated tremendous interest. Many earlier investigations …

Polyunsaturated lipids regulate membrane domain stability by tuning membrane order

KR Levental, JH Lorent, X Lin, AD Skinkle, MA Surma… - Biophysical journal, 2016 - cell.com
The plasma membrane (PM) serves as the functional interface between a cell and its
environment, hosting extracellular signal transduction and nutrient transport among a variety …

[HTML][HTML] Eicosapentaenoic acid and docosahexaenoic acid have distinct membrane locations and lipid interactions as determined by X-ray diffraction

SCR Sherratt, RP Mason - Chemistry and physics of lipids, 2018 - Elsevier
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) differentially influence lipid
oxidation, signal transduction, fluidity, and cholesterol domain formation, potentially due in …