Circulating biomarkers in the diagnosis and management of hepatocellular carcinoma

P Johnson, Q Zhou, DY Dao, YMD Lo - … reviews Gastroenterology & …, 2022 - nature.com
Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal causes of cancer-
related death worldwide. The treatment of HCC remains challenging and is largely …

Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy

AG Singal, F Kanwal, JM Llovet - Nature reviews Clinical oncology, 2023 - nature.com
Hepatocellular carcinoma (HCC) mortality rates are increasing globally, and particularly in
the Western world. Cirrhosis remains the predominant risk factor for HCC. However …

AASLD practice guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma

AG Singal, JM Llovet, M Yarchoan, N Mehta… - Hepatology, 2023 - journals.lww.com
This guidance document provides an updated approach to the prevention, diagnosis, and
treatment of hepatocellular carcinoma (HCC). The prior American Association for the Study …

Breakthroughs in hepatocellular carcinoma therapies

AG Singal, M Kudo, J Bruix - Clinical Gastroenterology and Hepatology, 2023 - Elsevier
Several breakthroughs in hepatocellular carcinoma (HCC) therapy across tumor stages
provide hope to improve its dismal prognosis. Although surgical and local ablative therapies …

AFP-L3 and DCP strongly predict early hepatocellular carcinoma recurrence after liver transplantation

JS Norman, PJ Li, P Kotwani, AM Shui, F Yao… - Journal of …, 2023 - Elsevier
Background & Aims Alpha-fetoprotein (AFP) predicts hepatocellular carcinoma (HCC)
recurrence after liver transplant (LT) but remains an imperfect biomarker. The role of DCP …

AFP-L3 and DCP are superior to AFP in predicting waitlist dropout in HCC patients: Results of a prospective study

N Mehta, P Kotwani, J Norman, A Shui, PJ Li… - Liver …, 2023 - journals.lww.com
In patients with HCC awaiting liver transplantation (LT), there is a need to identify
biomarkers that are superior to AFP in predicting prognosis. AFP-L3 and des-gamma …

Living Donor Liver Transplantation for Hepatocellular Carcinoma Within and Outside Traditional Selection Criteria: A Multicentric North American Experience

T Ivanics, MPAW Claasen, B Samstein… - Annals of …, 2024 - journals.lww.com
Objective: To evaluate long-term oncologic outcomes of patients post–living donor liver
transplantation (LDLT) within and outside standard transplantation selection criteria and the …

Development and validation of a REcurrent Liver cAncer Prediction ScorE (RELAPSE) following liver transplantation in patients with hepatocellular carcinoma …

BV Tran, D Moris, D Markovic, H Zaribafzadeh… - Liver …, 2023 - journals.lww.com
HCC recurrence following liver transplantation (LT) is highly morbid and occurs despite strict
patient selection criteria. Individualized prediction of post-LT HCC recurrence risk remains …

[HTML][HTML] Hepatocellular carcinoma, alpha fetoprotein, and liver allocation for transplantation: past, present and future

B Ruch, J Wagler, K Kumm, C Zhang, NN Katariya… - Current …, 2022 - mdpi.com
Hepatocellular carcinoma (HCC) is one of the leading indications for liver transplantation
and has been the treatment of choice due to the oncologic benefit for patients with advanced …

Role of protein induced by vitamin-K absence-II in transplanted patients with HCC not producing alpha-fetoprotein

Q Lai, T Ito, S Iesari, T Ikegami, D Nicolini… - Liver …, 2024 - journals.lww.com
Abstract Elevated Protein Induced by Vitamin-K Absence-II (PIVKA-II) has been shown to be
an adverse prognostic factor in HCC patients undergoing liver transplantation (LT). No …