It has been known for decades that the tumor extracellular matrix (ECM) is dysfunctional
leading to loss of tissue architecture and promotion of tumor growth. The altered ECM and …

The development of cancer immunotherapy, particularly immune checkpoint blockade
therapy, has made major breakthroughs in the therapy of cancers. However, less than one …

Glioblastoma (GBM), an aggressive high-grade glial tumor, is resistant to therapy and has a
poor prognosis due to its universal recurrence rate. GBM cells interact with the non-cellular …

Simple Summary Development of new therapeutics to treat osteosarcoma is fundamental to
decreasing its current health impact. 3D in vitro models are gaining tremendous momentum …

Simple Summary The tumor microenvironment comprises numerous different cellular
players that engage transformed cancer cells and may exert pro-vs anti-tumor functions …

Simple Summary Melanoma is an aggressive form of skin cancer and the leading cause of
skin cancer-related deaths. Current therapies, including those targeting oncogenic pathways …

Tumor recurrence is a paradoxical function of a machinery, whereby a small proportion of
the cancer cell population enters a resistant, dormant state, persists long-term in this …

The tumor microenvironment is a complex structure composed of the extracellular matrix
(ECM) and nontumoral cells (notably cancer-associated fibroblasts (CAFs) and immune …

The tumor microenvironment (TME) composed of different types of cells embedded in
extracellular matrix (ECM) has crucial effects on cancer growth and metastasis. ECM is …

Background A disintegrin-like and metalloproteinase domain with thrombospondin type 1
motifs (ADAMTS)-like proteins, including ADAMTSL1-6 and papilin, which are part of the …