Endocrine-disrupting chemicals (EDCs) interfere with hormone receptors and are
associated with a variety of adverse health effects. Therefore, there is a rising global concern …

The condensation of propargylated vanillin with differently substituted acetophenones
produced the corresponding chalcones which were reacted with substituted benzyl azides …

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a promising
target for the treatment of different neurodegenerative diseases, especially Alzheimer's …

The emergence of bioinformatics tools and methods has impressively increased the
chances of the discovery of new antimalarial drugs that can act through new modes of …

Virtual screening is emerging as a highly applied technique for the search of hits since it
significantly reduces the time required for the establishment of novel, effective compounds …

The use of computational chemistry can potentially reduce the cost of laboratory work and
clinical trials, while speeding up the process of drug discovery. This can be achieved by the …

The aim of this work was to be combine two pharmocophoric nuclei viz, triazole and
chalcone and evaluate their antitubercular activity. Propargylated vanillin was condensed …

Introduction: Telework, also known as remote work, distance work, telecommuting, was
gaining popularity already before the COVID-19 pandemic. Despite benefits, telework can …

V teoretické části se diplomová práce zabývá virtuálním screeningem a jeho rozdělením na
structure-based drug design (SBDD) a ligand-based drug design (LBDD), přičemž větší …