The historical reliance of biological research on the use of animal models has sometimes
made it challenging to address questions that are specific to the understanding of human …

Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

The ability to study human post-implantation development remains limited owing to ethical
and technical challenges associated with intrauterine development after implantation …

In vitro cultured stem cells with distinct developmental capacities can contribute to
embryonic or extraembryonic tissues after microinjection into pre-implantation mammalian …

Investigating human development is a substantial scientific challenge due to the technical
and ethical limitations of working with embryonic samples. In the face of these difficulties …

After fertilization, the quiescent zygote experiences a burst of genome activation that initiates
a short-lived totipotent state. Understanding the process of totipotency in human cells would …

The mammalian body plan is established shortly after the embryo implants into the maternal
uterus, and our understanding of post-implantation developmental processes remains …

Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …

BACKGROUND Mammalian germ cells differentiate into oocytes in females and
spermatozoa in males. An oocyte and a spermatozoon fuse to form a zygote and then …

Human stem cell-derived blastoids display similar morphology and cell lineages to normal
blastocysts. However, the ability to investigate their developmental potential is limited. Here …