Carcinogenesis, a multi-step phenomenon, characterized by alterations at genetic level and
affecting the main intracellular pathways controlling cell growth and development. There are …

Mathematical models of chronic myeloid leukemia (CML) cell population dynamics are
being developed to improve CML understanding and treatment. We review such models in …

When mammalian tissues are infected by bacteria or fungi, inflammatory cytokines are
released that cause circulating neutrophils to invade the infected tissue. The cytosolic …

The ability of oncogenic proteins to regulate the rate of translation of specific mRNA subsets
may be a rapid and efficient mechanism to modulate the levels and, in many cases, the …

Chronic myeloid leukemia (CML) is characterized by a specific chromosome translocation,
and its pathobiology is considered comparatively well understood. Thus, quantitative …

Chronic myeloid leukemia is a disorder that develops when a hematopoietic stem cell
acquires the Philadelphia chromosome carrying the chimeric BCR/ABL oncogene leading to …

Abstract The t (9; 22) translocation that causes chronic myeloid leukemia (CML) drives both
transformation and the progression process that eventually results in the disease changing …

Chronic myeloid leukaemia (CML) is caused by the Bcr-Abl translocation. It is otherwise
genetically normal. CML is unusual in being a “single-hit” malignancy, ie although other …

НАЦІОНАЛЬНА АКАДЕМІЯ НАУК УКРАЇНИ ІНСТИТУТ МОЛЕКУЛЯРНОЇ БІОЛОГІЇ ТА Page 1
НАЦІОНАЛЬНА АКАДЕМІЯ НАУК УКРАЇНИ ІНСТИТУТ МОЛЕКУЛЯРНОЇ БІОЛОГІЇ ТА …

Chronic myeloid leukaemia (CML) is characterised by the presence of the Philadelphia
chromosome which harbours the Bcr-Abl oncogene. BCR-ABL is a constitutively active …