Integral membrane proteins are involved in a plethora of biological processes including
cellular signalling, molecular transport, and catalysis. Many of these functions are mediated …

Single-particle cryogenic electron-microscopy (cryo-EM) has emerged as a powerful
technique for the structural characterisation of membrane proteins, especially for targets …

Ubiquitin ligases (E3s) are pivotal specificity determinants in the ubiquitin system by
selecting substrates and decorating them with distinct ubiquitin signals. However, structure …

Munc13-1 is essential for vesicle docking and fusion at the active zone of synapses. Here,
we report that Munc13-1 self-assembles into molecular clusters within diacylglycerol-rich …

Chemical cross-linking reactions (XL) are an important strategy for studying protein-protein
interactions (PPIs), including low abundant sub-complexes, in structural biology. However …

Lassa virus is a negative-strand RNA virus with only four structural proteins that causes
periodic outbreaks in West Africa. The nucleoprotein (NP) encapsidates the viral genome …

G-protein metallochaperones are essential for the proper maturation of numerous
metalloenzymes. The G-protein chaperone MMAA in humans (MeaB in bacteria) uses GTP …

In meiotic homologous recombination (HR), BRCA2 facilitates loading of the recombinases
RAD51 and DMC1 at the sites of double-strand breaks (DSBs). The HSF2BP-BRME1 …

The main protease (M pro) of SARS-CoV-2 is critical in the virus's replication cycle,
facilitating the maturation of polyproteins into functional units. Due to its conservation across …

Mass photometry is a versatile mass measurement technology that enables the study of
biomolecular interactions and complex formation in solution without labels. Mass photometry …