Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action

JF Chen, SW Wu, ZM Shi, B Hu - Chinese Medicine, 2023 - Springer
Colorectal cancer (CRC) is a disease with complex pathogenesis, it is prone to metastasis,
and its development involves abnormalities in multiple signaling pathways. Surgery …

Health benefits of saponins and its mechanisms: perspectives from absorption, metabolism, and interaction with gut

Y Zhang, R Hao, J Chen, S Li, K Huang… - Critical Reviews in …, 2023 - Taylor & Francis
Saponins, consisting of sapogenins as their aglycones and carbohydrate chains, are widely
found in plants and some marine organisms. Due to the complexity of the structure of …

The therapeutic potential of natural products for treating pancreatic cancer

X He, N Wang, Y Zhang, X Huang… - Frontiers in …, 2022 - frontiersin.org
Pancreatic cancer is one of the most malignant tumors of the digestive tract, with the poor
prognosis and low 5-year survival rate less than 10%. Although surgical resection and …

Saponins and their derivatives: potential candidates to alleviate anthracycline-induced cardiotoxicity and multidrug resistance

PR Qu, ZL Jiang, PP Song, LC Liu, M Xiang… - Pharmacological …, 2022 - Elsevier
Anthracyclines (ANTs) continue to play an irreplaceable role in oncology treatment.
However, the clinical application of ANTs has been limited. In the first place, ANTs can …

A review of ginsenosides from Panax ginseng in the treatment of inflammatory bowel disease

Z Niu, Y Liu, R Shen, X Jiang, Y Wang, Z He, J Li, Y Hu… - Phytomedicine, 2024 - Elsevier
Background Inflammatory bowel disease (IBD) is characterized by a chronic inflammation of
the intestine, which significantly affects patients' quality of life. As a perennial plant with the …

Ginsenoside Rb1 from Panax notoginseng Suppressed TNF-α-Induced Matrix Metalloproteinase-9 via the Suppression of Double-Strand RNA-Dependent Protein …

WT Sun, CLH Yang, TCT Or, D Luo, JCB Li - Molecules, 2022 - mdpi.com
Chronic inflammation is commonly accompanied by the stimulation of matrix
metalloproteinases (MMPs) production and the degradation of the extracellular matrix. The …

Panax notoginseng: panoramagram of phytochemical and pharmacological properties, biosynthesis, and regulation and production of ginsenosides

G Wei, G Zhang, M Li, Y Zheng, W Zheng… - Horticulture …, 2024 - academic.oup.com
Panax notoginseng is a famous perennial herb widely used as material for medicine and
health-care food. Due to its various therapeutic effects, research work on P. notoginseng has …

A Comprehensive Review of Phytochemicals Targeting Macrophages for the Regulation of Colorectal Cancer Progression

Y Yang, M Zhao, Q Kuang, F You, Y Jiang - Phytomedicine, 2024 - Elsevier
Background Phytochemicals are natural compounds derived from plants, and are now at the
forefront of anti-cancer research. Macrophage immunotherapy plays a crucial role in the …

Pharmacological effects of ginseng and ginsenosides on intestinal inflammation and the immune system

L Zhao, T Zhang, K Zhang - Frontiers in Immunology, 2024 - frontiersin.org
Intestinal inflammatory imbalance and immune dysfunction may lead to a spectrum of
intestinal diseases, such as inflammatory bowel disease (IBD) and gastrointestinal tumors …

Yunnan baiyao exerts anti-glioma activity by inducing autophagy-dependent necroptosis

N Zhang, K Guo, W Lin, Z Wang, F Zhang… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Yunnan Baiyao (YB), a traditional herbal
formulation, has been used for over a century to manage bleeding and enhance blood …