Serial sampling of serum protein biomarkers for monitoring human traumatic brain injury dynamics: a systematic review
Background The proteins S100B, neuron-specific enolase (NSE), glial fibrillary acidic
protein (GFAP), ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), and neurofilament light …
protein (GFAP), ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), and neurofilament light …
Blood biomarkers for brain injury: What are we measuring?
K Kawata, CY Liu, SF Merkel, SH Ramirez… - Neuroscience & …, 2016 - Elsevier
Accurate diagnosis for mild traumatic brain injury (mTBI) remains challenging, as prognosis
and return-to-play/work decisions are based largely on patient reports. Numerous …
and return-to-play/work decisions are based largely on patient reports. Numerous …
A serum protein biomarker panel improves outcome prediction in human traumatic brain injury
E Thelin, F Al Nimer, A Frostell, H Zetterberg… - Journal of …, 2019 - liebertpub.com
Brain-enriched protein biomarkers of tissue fate are being introduced clinically to aid in
traumatic brain injury (TBI) management. The aim of this study was to determine how …
traumatic brain injury (TBI) management. The aim of this study was to determine how …
Biomarkers for severity of neonatal hypoxic-ischemic encephalopathy and outcomes in newborns receiving hypothermia therapy
LF Chalak, PJ Sánchez, B Adams-Huet… - The Journal of …, 2014 - Elsevier
Objective To evaluate serum neuronal and inflammatory biomarkers to determine whether
measurements of umbilical cords at birth can stratify severity of hypoxic-ischemic …
measurements of umbilical cords at birth can stratify severity of hypoxic-ischemic …
Human traumatic brain injury induces autoantibody response against glial fibrillary acidic protein and its breakdown products
Z Zhang, JS Zoltewicz, S Mondello, KJ Newsom… - PloS one, 2014 - journals.plos.org
The role of systemic autoimmunity in human traumatic brain injury (TBI) and other forms of
brain injuries is recognized but not well understood. In this study, a systematic investigation …
brain injuries is recognized but not well understood. In this study, a systematic investigation …
RNA sequence analysis of human huntington disease brain reveals an extensive increase in inflammatory and developmental gene expression
A Labadorf, AG Hoss, V Lagomarsino, JC Latourelle… - PloS one, 2015 - journals.plos.org
Huntington's Disease (HD) is a devastating neurodegenerative disorder that is caused by an
expanded CAG trinucleotide repeat in the Huntingtin (HTT) gene. Transcriptional …
expanded CAG trinucleotide repeat in the Huntingtin (HTT) gene. Transcriptional …
GFAP and S100B in the acute phase of mild traumatic brain injury
Z Metting, N Wilczak, LA Rodiger, JM Schaaf… - Neurology, 2012 - AAN Enterprises
Objective: The biomarkers glial fibrillary acid protein (GFAP) and S100B are increasingly
used as prognostic tools in severe traumatic brain injury (TBI). Data for mild TBI are scarce …
used as prognostic tools in severe traumatic brain injury (TBI). Data for mild TBI are scarce …
Neurochemical biomarkers in spinal cord injury
Study design This is a narrative review of the literature on neurochemical biomarkers in
spinal cord injury (SCI). Objectives The objective was to summarize the literature on …
spinal cord injury (SCI). Objectives The objective was to summarize the literature on …
Serum glial fibrillary acidic protein is a highly specific biomarker for traumatic brain injury in humans compared with S-100B and neuron-specific enolase
M Honda, R Tsuruta, T Kaneko… - Journal of Trauma …, 2010 - journals.lww.com
Background: Serum glial fibrillary acidic protein (GFAP) is a specific predictor of brain
damage and neurologic outcome in patients with traumatic brain injury (TBI). In this study …
damage and neurologic outcome in patients with traumatic brain injury (TBI). In this study …
Blood-based diagnostics of traumatic brain injuries
S Mondello, U Muller, A Jeromin, J Streeter… - Expert review of …, 2011 - Taylor & Francis
Traumatic brain injury is a major health and socioeconomic problem that affects all societies.
However, traditional approaches to the classification of clinical severity are the subject of …
However, traditional approaches to the classification of clinical severity are the subject of …