Exposure to stress is one of the greatest contributing factors to developing a psychiatric
disorder, particularly in susceptible populations. Enhancing resilience to stress could be a …

Major depressive disorder (MDD) and bipolar disorder (BD) are the most common mood
disorders. They are etiologically related, but clinically distinct psychiatric illnesses. Their …

Background Variation within the CYP2C19 gene has been linked to differential metabolism
of selective serotonin reuptake inhibitors (SSRIs). Pharmacogenetic recommendations …

Along with the typical biochemical alterations that occur during pregnancy, certain metabolic
changes might be associated with the development of several psychiatric disorders …

Scaffolds hybridization is a well-known drug design strategy for antitumor agents. Herein,
series of novel indolyl-pyrimidine hybrids were synthesized and evaluated in vitro and in …

Metabolomics provides valuable tools for the study of drug effects, unraveling the
mechanism of action and variation in response due to treatment. In this study we used …

Emerging insights from metabolomic-based studies of major depression disorder (MDD) are
mainly related to biochemical processes such as energy or oxidative stress, in addition to …

Depression is a chronic, relapsing mental illness, often accompanied by loss of appetite,
increased fatigue, insomnia and poor concentration. Here, we performed serum and urine …

Recently, we have shown that ketamine given prior to stress exposure protects against the
development of depressive-like behavior in mice. These data suggest that it may be possible …

Depression is the most common disabling psychiatric disease, with a high prevalence and
mortality. Chronic unpredictable mild stress (CUMS) is a well-accepted method used to …