Only a fraction of oocytes present in the ovaries at birth are ever ovulated during the lifetime
of a female mammal. In vitro maturation (IVM) offers the possibility to exploit what is a largely …

The basic pattern of metabolism in mammalian oocytes and early embryos was established
in the 1960s and 1970s, largely in terms of the consumption of oxygen and the utilisation of …

Recent studies have shown that l-proline (proline) is an antioxidant to protect cells from
oxidative stress in vivo and in vitro. Glutathione (GSH) is a major cellular redox regulator …

The molecular mechanisms controlling the transition from meiotic arrest to meiotic
resumption in mammalian oocytes have not been fully elucidated. Single-cell omics …

Background Mancozeb (MZ) is a fungicide that belongs to the subclass of metal (Mn/Zn)
ethylene-bis-dithiocarbamate pesticides. In mouse and human granulosa cells (GCs) …

Dietary supplementation is the most feasible method to improve oocyte function and
developmental potential in vivo. During three experiments, oocytes were collected from …

Acrylamide (ACR) is a chemical compound with severe neurotoxicity, genotoxicity,
carcinogenicity and reproductive toxicity. Recent studies showed that ACR impairs the …

Oocyte quality is one of the important factors in female fertility, in vitro maturation (IVM), and
subsequent embryonic development. In the present study, we assessed whether acetyl-l …

Objective The aim of this study was to investigate which factors contribute to the incidence of
immature oocytes (germinal vesicle-GV-and metaphase I-MI-) and how they impact the …

Lipolytic metabolic conditions are traditionally associated with elevated non-esterified fatty
acid (NEFA) concentrations, but may also be accompanied by hyperglycaemia in obesity or …