Synthesis and evaluation of cerebroprotective activity of novel 6, 7-dimethoxyquinazolin-4 (3H)-one derivatives containing residues of amino acids and dipeptides

AS Chiriapkin, IP Kodonidi, DI Pozdnyakov - Chimica Techno Acta. 2022 …, 2022 - elar.urfu.ru
Neurodegenerative processes of the central nervous system are an important socially
significant problem of modern society. They cause many diseases, such as Alzheimer's …

Copper Catalyst-Supported Modified Magnetic Chitosan for the Synthesis of Novel 2-Arylthio-2,3-dihydroquinazolin-4(1H)-one Derivatives via Chan–Lam Coupling

N Ghasemi, A Yavari, S Bahadorikhalili, A Moazzam… - Inorganics, 2022 - mdpi.com
In this paper, magnetic chitosan is used as a support for the immobilization of copper
catalyst (Cu@ MChit). The fabricated catalyst is successfully synthesized and characterized …

Design, synthesis, in silico ADME, DFT, molecular dynamics simulation, anti-tyrosinase, and antioxidant activity of some of the 3-hydroxypyridin-4-one hybrids in …

R Fazel, B Hassani, F Zare, H Jokar Darzi… - Journal of …, 2023 - Taylor & Francis
Tyrosinase is the rate-limiting enzyme in synthesizing melanin. Melanin is responsible for
changing the color of fruits and vegetables and protecting against skin photo …

Newly designed quinazolinone derivatives as novel tyrosinase inhibitor: synthesis, inhibitory activity, and mechanism

Y Huang, J Yang, Y Chi, C Gong, H Yang, F Zeng… - Molecules, 2022 - mdpi.com
We synthesized a series of quinazolinone derivates as tyrosinase inhibitors and evaluated
their inhibition constants. We synthesized 2-(2, 6-dimethylhepta-1, 5-dien-1-yl) quinazolin-4 …

A Comparative DFT Study on the Antioxidant Activity of Some Novel 3‐Hydroxypyridine‐4‐One Derivatives

MM Dehkordi, MH Asgarshamsi, A Fassihi… - Chemistry & …, 2022 - Wiley Online Library
The current study on the antioxidant activity of kojic acid and 3‐hydroxypyridine‐4‐one
derivatives was performed by implementation of density functional theory calculations with …

Synthesis and tyrosinase inhibitory activities of novel isopropylquinazolinones

A Hashemi, M Noori, N Dastyafteh, SE Sadat-Ebrahimi… - BMC chemistry, 2023 - Springer
To find new anti-browning and whitening agents in this study, new series of
isopropylquinazolinone derivatives were designed and synthesized. All derivatives were …

Access to new phosphonate-and imidazolidine-benzopyrimidinone derivatives as antityrosinase and anti-acetylcholinesterase agents: Design, synthesis and …

S Chortani, A Hajlaoui, S Jlizi, AH Harrath… - Journal of Molecular …, 2022 - Elsevier
To discover new acetylcholinesterase and tyrosinase inhibitors, a series of dialkyl
phosphonate-benzopyrimidinones 4a-b was prepared via Michaelis-Arbuzov rearrangement …

Green Synthesis of 2‐Thioxo‐4‐quinazolinone Derivatives in Water

K Makiyama, Y Mimura, Y Tomotani… - ChemistrySelect, 2023 - Wiley Online Library
A series of biologically important 3‐substituted‐2‐thixo‐4‐quinazolinones have been
synthesized starting from methyl 2‐isothicyanatobenzoate and amines without the use of …

Undescribed alkyne-geranylcyclohexenetriols from the endophyte Diaporthe caulivora 09F0132 and their anti-melanogenic activity

SS Yang, YF Chen, HH Ko, HC Wu, SY Hsieh, MD Wu… - Phytochemistry, 2022 - Elsevier
To explore valuable endophytic fungus from Formosan Lauraceous plants as natural
medicinal products, the fungus, Diaporthe caulivora isolated from leaves of Neolitsea …

Antioxidant and Anti-Aging Phytoconstituents from Faucaria tuberculosa: In Vitro and In Silico Studies

HS Ahmed, H Abouzeid, MA Mansour, AI Owis, E Amin… - Molecules, 2023 - mdpi.com
Research targeting natural cosmeceuticals is now increasing due to the safety and/or limited
side effects of natural products that are highly valued in cosmetology. Within a research …