Cystic fibrosis (CF) is a life-threatening autosomal-recessive disease caused by mutations in
a single gene encoding cystic fibrosis transmembrane conductance regulator (CFTR). CF …

Epithelial transport is a multifaceted process crucial for maintaining normal physiological
functions in the human body. This comprehensive review delves into the pathophysiological …

Lipid nanoparticles (LNPs) have emerged as a viable, clinically-validated platform for the
delivery of mRNA therapeutics. LNPs have been utilized as mRNA delivery systems for …

Digestive system diseases arise primarily through the interplay of genetic and environmental
influences; there is an urgent need in elucidating the pathogenic mechanisms of these …

Exogenously delivered mRNA-based drugs are emerging as a new class of therapeutics
with the potential to treat several diseases. Over the last decade, advancements in the …

Cystic fibrosis (CF) is a high-prevalence disease characterized by significant lung
remodeling, responsible for high morbidity and mortality worldwide. The lung structural …

This review provides an update on recent developments of RNA-and DNA-based
methodologies and their intracellular targets in the context of cystic fibrosis (CF) lung …

In the lungs, defective CFTR associated with cystic fibrosis (CF) represents the nidus for
abnormal mucus clearance in the airways and consequently a progressive lung disease …

DNA repair in mammalian cells involves the coordinated action of a range of complex
cellular repair machinery. Our understanding of these DNA repair processes has advanced …

Lentiviral vectors are attractive delivery vehicles for cystic fibrosis gene therapy owing to
their low immunogenicity and ability to integrate into the host cell genome, thereby …