Asthma exacerbations: pathogenesis, prevention, and treatment

JR Castillo, SP Peters, WW Busse - The Journal of Allergy and Clinical …, 2017 - Elsevier
Guideline-based management of asthma focuses on disease severity and choosing the
appropriate medical therapy to control symptoms and reduce the risk of exacerbations …

Putting the efficacy of psychiatric and general medicine medication into perspective: review of meta-analyses

S Leucht, S Hierl, W Kissling, M Dold… - The British Journal of …, 2012 - cambridge.org
BackgroundThe efficacy of psychopharmacological treatments has been called into
question. Psychiatrists are unfamiliar with the effectiveness of common medical drugs …

Quantifying the proportion of severe asthma exacerbations attributable to inhaled corticosteroid nonadherence

LK Williams, EL Peterson, K Wells… - Journal of Allergy and …, 2011 - Elsevier
BACKGROUND: Asthma is an inflammatory condition often punctuated by episodic
symptomatic worsening, and accordingly, patients with asthma might have waxing and …

Acute exacerbations of asthma: epidemiology, biology and the exacerbation‐prone phenotype

RH Dougherty, JV Fahy - Clinical & Experimental Allergy, 2009 - Wiley Online Library
Asthma is a highly prevalent chronic respiratory disease affecting 300 million people world‐
wide. A significant fraction of the cost and morbidity of asthma derives from acute care for …

Effect of budesonide in combination with formoterol for reliever therapy in asthma exacerbations: a randomised controlled, double-blind study

KF Rabe, T Atienza, P Magyar, P Larsson, C Jorup… - The Lancet, 2006 - thelancet.com
Background The contributions of as-needed inhaled corticosteroids and long-acting β2
agonists (LABA) to asthma control have not been fully established. We compared the …

[HTML][HTML] Budesonide/formoterol for maintenance and relief in uncontrolled asthma vs. high-dose salmeterol/fluticasone

J Bousquet, LP Boulet, MJ Peters, H Magnussen… - Respiratory …, 2007 - Elsevier
BACKGROUND: Budesonide/formoterol maintenance and reliever therapy (Symbicort
SMART®) improves asthma control compared with fixed-dose inhaled corticosteroid/long …

Effect of ADRB2 polymorphisms on response to longacting β2-agonist therapy: a pharmacogenetic analysis of two randomised studies

ER Bleecker, DS Postma, RM Lawrance, DA Meyers… - The Lancet, 2007 - thelancet.com
Background New evidence has suggested that people with asthma who are homozygous for
arginine at aminoacid 16 of the β 2-adrenergic receptor (ADRB2) might not benefit from …

Exercise-induced bronchoconstriction in athletes

JP Parsons, JG Mastronarde - Chest, 2005 - Elsevier
Exercise-induced bronchoconstriction (EIB) describes airway narrowing that occurs in
association with exercise. EIB occurs in up to 90% of asthmatic patients and is estimated to …

[HTML][HTML] How effective are common medications: a perspective based on meta-analyses of major drugs

S Leucht, B Helfer, G Gartlehner, JM Davis - BMC medicine, 2015 - Springer
The vastness of clinical data and the progressing specialization of medical knowledge may
lead to misinterpretation of medication efficacy. To show a realistic perspective on drug …

Montelukast as add-on therapy to inhaled corticosteroids in the treatment of mild to moderate asthma: a systematic review

S Joos, A Miksch, J Szecsenyi, B Wieseler, U Grouven… - Thorax, 2008 - thorax.bmj.com
Objective: To systematically review the evidence for the medium to long term benefits and
risks of montelukast as add-on therapy to inhaled corticosteroids (ICS) in comparison with …