Metabolism dysregulation in retinal diseases and related therapies

Y Chen, NJ Coorey, M Zhang, S Zeng, MC Madigan… - Antioxidants, 2022 - mdpi.com
The human retina, which is part of the central nervous system, has exceptionally high energy
demands that requires an efficient metabolism of glucose, lipids, and amino acids …

Is Cancer Metabolism an Atavism?

E Fanchon, A Stéphanou - Cancers, 2024 - mdpi.com
The atavistic theory of cancer posits that cancer emerges and progresses through the
reversion of cellular phenotypes to more ancestral types with genomic and epigenetic …

The cleavage-specific tau 12A12mAb exerts an anti-amyloidogenic action by modulating the endocytic and bioenergetic pathways in Alzheimer's disease mouse …

V Latina, A Atlante, F Malerba, F La Regina… - International Journal of …, 2023 - mdpi.com
Beyond deficits in hippocampal-dependent episodic memory, Alzheimer's Disease (AD)
features sensory impairment in visual cognition consistent with extensive neuropathology in …

miR‐22 Suppresses EMT by Mediating Metabolic Reprogramming in Colorectal Cancer through Targeting MYC‐Associated Factor X

S Xia, X Wang, Y Wu, T Zhou, H Tian, Z Liu… - Disease …, 2022 - Wiley Online Library
Colorectal cancer (CRC) is one of the most frequent gastrointestinal cancers. MicroRNAs
(miRNAs) have been proved to be unusually expressed in CRC progression and thus alter …

[HTML][HTML] An analysis of metabolic changes in the retina and retinal pigment epithelium of aging mice

KA Tsantilas, WM Cleghorn… - … & Visual Science, 2021 - iovs.arvojournals.org
Purpose: The purpose of this study was to present our hypothesis that aging alters metabolic
function in ocular tissues. We tested the hypothesis by measuring metabolism in aged …

Propofol prevents the growth, migration, invasion, and glycolysis of colorectal cancer cells by downregulating lactate dehydrogenase both in vitro and in vivo

Z Wu, H Wang, ZA Shi, Y Li - Journal of Oncology, 2022 - Wiley Online Library
Colorectal cancer (CRC) is one of the most frequently diagnosed gastrointestinal
malignancies worldwide and has high rates of morbidity and mortality. Propofol has been …

Decreased glucose metabolism and glutamine synthesis in the retina of a transgenic mouse model of Alzheimer's disease

ALM Tams, B Sanz-Morello, EW Westi… - Cellular and Molecular …, 2022 - Springer
Visual changes are some of the earliest symptoms that patients with Alzheimer's disease
(AD) experience. Pathophysiological processes such as amyloid-β plaque formation …

The daily gene transcription cycle in mouse retina

Z Wang, S Ji, Y Huang, K Liao, Z Cui, F Chu… - Experimental Eye …, 2021 - Elsevier
Many physiological retinal processes, such as outer segment disk shedding and visual
sensitivity, exhibit a daily rhythm. However, the detailed transcriptome dynamics and related …

circATP2A2 promotes osteosarcoma progression by upregulating MYH9

X Cao, X Meng, P Fu, L Wu, Z Yang, H Chen - Open Medicine, 2021 - degruyter.com
Osteosarcoma (OS) is a highly metastatic primary malignant tumor. CircRNA
hsa_circ_0028173 (circATP2A2) has been uncovered to be related to the advancement of …

[HTML][HTML] Markers of Hypoxia and Metabolism Correlate With Cell Differentiation in Retina and Lens Development

TA Gardiner, T Branagh, N Tipping… - Frontiers in …, 2022 - frontiersin.org
Recent studies have provided novel insights of co-development of the neural and vascular
elements of the retina. Knowledge of these relationships are crucial to understand the …