Diabetes mellitus is characterized by a lack of insulin causing elevated blood glucose, often
with associated insulin resistance. Over time, especially in genetically susceptible …

BACKGROUND: Diabetes mellitus is a systemic disorder associated with inflammation and
oxidative stress which may target many organs such as the kidney, retina, and the vascular …

Purpose: The purpose of this study was to evaluate the therapeutic potential of oral curcumin
(1 g/kg body weight of rat) in the prevention and treatment of streptozotocin-induced diabetic …

Diabetes mellitus is a chronic, progressive, incompletely understood metabolic disorder
whose prevalence has been increasing steadily worldwide. Even though little attention has …

The major clinical associations with the progression of diabetic kidney disease (DKD) are
glycemic control and systemic hypertension. Recent studies have continued to emphasize …

Mesangial cells (MCs) play a central role in the physiology and pathophysiology of
endothelin-1 (ET-1) in the kidney. MCs release ET-1 in response to a variety of factors, many …

Abstract Background. Hydrogen sulfide (H2S) is considered as the third gasotransmitter after
nitric oxide and carbon monoxide. This gas molecule participates in the regulation of renal …

In patients with type 1 and type 2 diabetes mellitus (DM), respiratory function abnormalities
have been reported with regard to lung volumes, pulmonary diffusing capacity, control of …

Excess collagen IV expression by mesangial cells contributes to diabetic
glomerulosclerosis. We hypothesized that in high glucose reactive oxygen species (ROS) …

Endothelin‐1 (ET‐1) plays an important role in tissue remodelling and fibrogenesis by
inducing synthesis of collagen I via protein kinase C (PKC). ET‐1 signals are transduced by …