Osteoarthritis (OA) is a complicated degenerative disease that affects whole joint tissue.
Currently, apart from surgical approaches to treat late stage OA, effective treatments to …

Cellular senescence is the inability of cells to proliferate, which has both beneficial and
detrimental effects on tissue development and homeostasis. Chronic accumulation of …

Ongoing pain is driven by the activation and modulation of pain-sensing neurons, affecting
physiology, motor function, and motivation to engage in certain behaviors. The complexity of …

Synovial joints are complex structures that enable normal locomotion. Following injury, they
undergo a series of changes, including a prevalent inflammatory response. This increases …

Background Strontium ranelate is currently used for osteoporosis. The international, double-
blind, randomised, placebo-controlled Strontium ranelate Efficacy in Knee OsteoarthrItis triAl …

Articular cartilage is a complex connective tissue with the fundamental functions of load
bearing, shock absorption and lubrication in joints. However, traumatic events, aging and …

Osteoarthritis (OA) is a multifactorial chronic disease primarily characterized by the
degeneration of articular cartilage. Currently, there is a lack of effective treatments for OA …

Objective To evaluate the safety and efficacy of intra-articular (IA) injection of allogeneic
adipose-derived stem cells (ADSCs) ELIXCYTE® for knee osteoarthritis. Methods This was …

Objective The FORWARD (FGF-18 Osteoarthritis Randomized Trial with Administration of
Repeated Doses) trial assessed efficacy and safety of the potential disease-modifying …

Although role of the microbiome in osteoarthritis is an area of intense study, no clear
mechanism of action has been determined. Increased understanding of how the two factors …