Control of human viral infections by natural killer cells

S Jost, M Altfeld - Annual review of immunology, 2013 - annualreviews.org
Natural killer (NK) cells are effector cells of the innate immune system and are important in
the control of viral infections. Their relevance is reflected by the multiple mechanisms …

Immunology of hepatitis B virus and hepatitis C virus infection

B Rehermann, M Nascimbeni - Nature Reviews Immunology, 2005 - nature.com
More than 500 million people worldwide are persistently infected with the hepatitis B virus
(HBV) and/or hepatitis C virus (HCV) and are at risk of developing chronic liver disease …

The liver as a lymphoid organ

IN Crispe - Annual review of immunology, 2009 - annualreviews.org
The liver receives blood from both the systemic circulation and the intestine, and in
distinctive, thin-walled sinusoids this mixture passes over a large macrophage population …

Immunobiology and pathogenesis of viral hepatitis

LG Guidotti, FV Chisari - Annu. Rev. Pathol. Mech. Dis., 2006 - annualreviews.org
Among the many viruses that are known to infect the human liver, hepatitis B virus (HBV)
and hepatitis C virus (HCV) are unique because of their prodigious capacity to cause …

Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence

B Rehermann - The Journal of clinical investigation, 2009 - Am Soc Clin Investig
Since the identification of the hepatitis C virus (HCV) 20 years ago, much progress has been
made in our understanding of its life cycle and interaction with the host immune system …

NKG2A is a NK cell exhaustion checkpoint for HCV persistence

C Zhang, X Wang, S Li, T Twelkmeyer, W Wang… - Nature …, 2019 - nature.com
Exhaustion of cytotoxic effector natural killer (NK) and CD8+ T cells have important functions
in the establishment of persistent viral infections, but how exhaustion is induced during …

Adaptive immune responses in acute and chronic hepatitis C virus infection

DG Bowen, CM Walker - Nature, 2005 - nature.com
The hepatitis C virus (HCV) persists in the majority of infected individuals and is a significant
cause of human illness and death globally. Recent studies have yielded important insights …

[HTML][HTML] Pathogenesis and prevention of hepatitis C virus-induced hepatocellular carcinoma

Y Hoshida, BC Fuchs, N Bardeesy, TF Baumert… - Journal of …, 2014 - Elsevier
Hepatitis C virus (HCV) is one of the major aetiologic agents that causes hepatocellular
carcinoma (HCC) by generating an inflammatory, fibrogenic, and carcinogenic tissue …

The tetraspanin web modulates immune-signalling complexes

S Levy, T Shoham - Nature Reviews Immunology, 2005 - nature.com
The tetraspanin web represents a new concept of molecular interactions in the immune
system. Whereas most surface immune-modulating molecules involve receptor–ligand …

Natural killer cell functional dichotomy in chronic hepatitis B and chronic hepatitis C virus infections

B Oliviero, S Varchetta, E Paudice, G Michelone… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: The phenotypic and functional characteristics of natural killer (NK)
cells in chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are …