Abstract KaKs_Calculator 3.0 is an updated toolkit that is capable of calculating selective
pressure on both coding and non-coding sequences. Similar to the nonsynonymous …

Abstract The National Genomics Data Center (NGDC), part of the China National Center for
Bioinformation (CNCB), provides a family of database resources to support global academic …

Crop plant breeding involves selecting and developing new plant varieties with desirable
traits such as increased yield, improved disease resistance, and enhanced nutritional value …

Intrahepatic cholestasis of pregnancy (ICP) is a female pregnancy-specific disorder that is
characterized by increased serum bile acid and adverse fetal outcomes. The aetiology and …

LncBook, a comprehensive resource of human long non-coding RNAs (lncRNAs), has been
used in a wide range of lncRNA studies across various biological contexts. Here, we present …

Abstract The 2022 Nucleic Acids Research Database Issue contains 185 papers, including
87 papers reporting on new databases and 85 updates from resources previously published …

The poor efficacy of chimeric antigen receptor T-cell therapy (CAR T) for solid tumors is due
to insufficient CAR T cell tumor infiltration, in vivo expansion, persistence, and effector …

Pollen-pistil interactions establish interspecific/intergeneric pre-zygotic hybridization barriers
in plants. The rejection of undesired pollen at the stigma is crucial to avoid outcrossing but …

All extant core-eudicot plants share a common ancestral genome that has experienced
cyclic polyploidizations and (re) diploidizations. Reshuffling of the ancestral core-eudicot …

Human cancer cell lines have long served as tools for cancer research and drug discovery,
but the presence and the source of intra-cell-line heterogeneity remain elusive. Here, we …