Gastric cancer remains a global killer with a shifting burden from the developed to the
developing world. The cancer develops along a multistage process that is defined by distinct …

A number of lines of evidence suggests that chronic inflammation contributes to the process
of carcinogenesis. In this article, this theme is explored with particular emphasis on the …

Abstract Activation of the Hedgehog (Hh) signalling pathway by sporadic mutations or in
familial conditions such as Gorlin's syndrome is associated with tumorigenesis in skin, the …

Helicobacter pylori (H. pylori) infection is the most common bacterial infection worldwide.
Persistent infection of the gastric mucosa leads to inflammatory processes and may remain …

Increase in reactive oxygen species plays an integral part in the inflammatory response, and
chronic inflammation increases cancer risk. Selenium-dependent glutathione peroxidase …

Approximately half of the world's population is infected with the stomach pathogen
Helicobacter pylori. Infection with H. pylori is the main risk factor for distal gastric cancer …

The current study tests the hypothesis that chronic atrophic gastritis from hypochlorhydria in
the gastrin-deficient mouse predisposes the stomach to gastric cancer. Gross morphology …

Helicobacter pylori, linked to gastric diseases, is targeted for probiotic treatment through
bacteriocin production. Bacteriocins have gained recognition for their non-toxic effects on …

Spasmolytic polypeptide/trefoil factor 2 (TFF2)-expressing metaplasia (SPEM) is a mucous-
secreting reparative lineage that emerges at the ulcer margin in response to gastric injury …

Obesity is a major modifiable risk factor for the development of numerous types of cancer.
Although many factors contribute to obesity-driven tumorigenesis, this review focuses on the …