In the almost 70 years since the first hints of its existence, the phosphoinositide,
phosphatidyl-D-myo-inositol 4, 5-bisphosphate has been found to be central in the …

Clathrin-mediated endocytosis enables selective uptake of molecules into cells in response
to changing cellular needs. It occurs through assembly of coat components around the …

Genetic variation is the major mechanism behind adaptation and evolutionary change. As
most proteins operate through interactions with other proteins, changes in protein complex …

Endocytosis is an essential eukaryotic process that maintains the homeostasis of the plasma
membrane proteome by vesicle-mediated internalization. Its predominant mode of operation …

Clathrin-mediated endocytosis is pivotal to signal transduction pathways between the
extracellular environment and the intracellular space. Evidence from live-cell imaging and …

ABSTRACT The lipid molecule phosphatidylinositol (4, 5)-bisphosphate [PI (4, 5) P 2]
controls all aspects of plasma membrane (PM) function in animal cells, from its selective …

Phosphoinositides are amphipathic lipid molecules derived from phosphatidylinositol that
represent low abundance components of biological membranes. Rather than serving as …

Peripheral membrane proteins are ubiquitous throughout cell biology and are required for a
variety of cellular processes such as signal transduction, membrane trafficking, and …

The prevalence of hyperlipidemia has increased significantly due to genetic, dietary,
nutritional and pharmacological factors, and has become one of the most common …

Cellular membrane interfacial processes are highly complex phenomena that are
challenging to explore in vivo, often limiting their mechanistic understanding. The plethora of …