The daily alternation between sleep and wakefulness is one of the most dominant features
of our lives and is a manifestation of the intrinsic 24 h rhythmicity underlying almost every …

As we age, we experience changes in our nighttime sleep and daytime wakefulness.
Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems even before …

Many processes in the human body—including brain function—are regulated over the 24-
hour cycle, and there are strong associations between disrupted circadian rhythms (for …

Epidemiological studies provided the first evidence suggesting a connection between the
circadian clock and human health. Mutant mice convincingly demonstrate the principle that …

Disturbances in the sleep–wake cycle and circadian rhythms are common symptoms of
Alzheimer Disease (AD), and they have generally been considered as late consequences of …

Alzheimer's disease (AD) is a devastating and irreversible cognitive impairment and the
most common type of dementia. Along with progressive cognitive impairment, dysfunction of …

Circadian rhythms are physiological and behavioural cycles generated by an endogenous
biological clock, the suprachiasmatic nucleus. The circadian system influences the majority …

Zebrafish (Danio rerio) is emerging as an increasingly successful model for translational
research on human neurological disorders. In this review, we appraise the high degree of …

Background Circadian disturbances are commonly seen in people with Alzheimer's disease
and have been reported in individuals without symptoms of dementia but with Alzheimer's …

Reports of sleep disturbances in attention deficit hyperactivity disorder (ADHD) are common
in both children and adults; however, the aetiology of such disturbances is poorly …