Alzheimer's disease (AD) is a global epidemic. Unfortunately, we are still without effective
treatments or a cure for this disease, which is having devastating consequences for patients …

The ability to probe defined neural circuits with both the spatial and temporal resolution
imparted by optogenetics has transformed the field of neuroscience. Although much …

With our increasing appreciation of the true complexity of diseases and pathophysiologies, it
is clear that this knowledge needs to inform the future development of pharmacotherapeutics …

Background: Sundown syndrome (SS) is the onset or worsening of behavioral symptoms in
the evening in patients with dementia. Objective: To identify the differential clinical profile of …

Disruption of circadian rhythms is commonly reported in individuals with Alzheimer's disease
(AD). Neurons in the primary circadian pacemaker, the suprachiasmatic nucleus (SCN) …

Circadian rhythms are recurring near‐24 hour patterns driven by an endogenous circadian
timekeeping system. The master pacemaker in this system is the hypothalamic …

Ambient light influences our mood, behavior, and cognition. Phototherapy has been
considered as an effective non-pharmacological intervention strategy in the restoration of …

Circadian rhythm is a 24-hour cycle of behavioral and physiological changes. Disrupted
sleep-wake patterns and circadian dysfunction are common in patients of Alzheimer …

Abstract Alzheimer's disease (AD), discovered by Alois Alzheimer in the early 1900s, is a
complex and progressive neurodegenerative disorder, characterized by episodes of …

Preventive neuroradiology is a new concept supported by growing literature. The main
rationale of preventive neuroradiology is the application of multimodal brain imaging toward …