Intestinal permeation enhancers (PEs) are one of the most widely tested strategies to
improve oral delivery of therapeutic peptides. This article assesses the intestinal permeation …

New therapeutic agents such as proteins, peptides, and nucleic acid-based agents are
being developed every year, making it vital to find a non-invasive route such as nasal or …

Introduction: Oral administration of most therapeutic peptides and proteins is mainly
restricted due to the enzymatic and absorption membrane barrier of the GI tract. In order to …

The eye, being one of the most intricate organs in the human body, hosts numerous
anatomical barriers and clearance mechanisms. This highlights the importance of devising a …

The epithelial barrier is the first innate defense of the gastrointestinal tract and selectively
regulates transport from the lumen to the underlying tissue compartments, restricting the …

Bile salts were first tested as epithelial permeation enhancers (PEs) for the intestine and
buccal routes over 20 years ago. They are not as popular as other PEs due to their non …

Purpose CriticalSorb™, with the principal component Solutol® HS15, is a novel mucosal
drug delivery system demonstrated to improve the bioavailability of selected biotherapeutics …

Abstract The Biopharmaceutics Classification System (BCS) classifies pharmaceutical
compounds based on their aqueous solubility and intestinal permeability. The BCS Class III …

Delivery of peptides by the oral route greatly appeals due to commercial, patient
convenience and scientific arguments. While there are over 60 injectable peptides marketed …

Oral delivery of macromolecules requires permeation enhancers (PEs) adaptable to
formulation. Sucrose laurate (SL)(D1216), a food grade surfactant, was assessed in Caco-2 …