Recombinant expressing angiopep-2 fused anti-VEGF single chain Fab (scFab) could cross blood–brain barrier and target glioma
X Ji, H Wang, Y Chen, J Zhou, Y Liu - AMB Express, 2019 - Springer
In 2009, the FDA approved bevacizumab for the treatment of adult patients diagnosed with
recurrent glioblastoma. However, the poor permeability of the macromolecules across the …
recurrent glioblastoma. However, the poor permeability of the macromolecules across the …
[HTML][HTML] Micelle carriers based on macrogol 15 hydroxystearate for ocular delivery of terbinafine hydrochloride: In vitro characterization and in vivo permeation
T Zhou, L Zhu, H Xia, J He, S Liu, S He, L Wang… - European Journal of …, 2017 - Elsevier
Non-ionic surfactant micelles are helpful for improving the diffusion of topically delivered
drugs through the cornea. This study aimed to develop terbinafine hydrochloride (TH) …
drugs through the cornea. This study aimed to develop terbinafine hydrochloride (TH) …
Enhanced permeation by amphiphilic surfactant is spatially heterogenous at membrane and cell level
R Cavanagh, S Shubber, D Vllasaliu… - Journal of Controlled …, 2022 - Elsevier
In the context of increased interest in permeability enhancement technologies to achieve
mucosal delivery of drugs and biologics, we report our study on effects of the amphiphilic …
mucosal delivery of drugs and biologics, we report our study on effects of the amphiphilic …
Evaluation of alkylmaltosides as intestinal permeation enhancers: comparison between rat intestinal mucosal sheets and Caco-2 monolayers
SB Petersen, G Nolan, S Maher, UL Rahbek… - European journal of …, 2012 - Elsevier
Alkylmaltosides are a class of non-ionic surfactant currently in clinical trials to improve nasal
permeation of peptide drugs, however few studies have detailed their potential effects on …
permeation of peptide drugs, however few studies have detailed their potential effects on …
Nasal administration and plasma pharmacokinetics of parathyroid hormone peptide PTH 1-34 for the treatment of osteoporosis
RG Pearson, T Masud, E Blackshaw, A Naylor… - Pharmaceutics, 2019 - mdpi.com
Nasal delivery of large peptides such as parathyroid 1-34 (PTH 1-34) can benefit from a
permeation enhancer to promote absorption across the nasal mucosa into the bloodstream …
permeation enhancer to promote absorption across the nasal mucosa into the bloodstream …
Size effect on lipid nanocapsule-mediated GLP-1 secretion from enteroendocrine L cells
L cells are enteroendocrine cells located throughout the gastrointestinal tract that secrete
physiologically important peptides. The most characterized peptides secreted by L cells are …
physiologically important peptides. The most characterized peptides secreted by L cells are …
In vitro and preclinical assessment of an intranasal spray formulation of parathyroid hormone PTH 1–34 for the treatment of osteoporosis
AJ Williams, F Jordan, G King, AL Lewis, L Illum… - International journal of …, 2018 - Elsevier
Osteoporosis treatment with PTH 1–34 injections significantly reduces the incidence of bone
fracture. Potential further reductions in fracture rate should be observed through nasal spray …
fracture. Potential further reductions in fracture rate should be observed through nasal spray …
[PDF][PDF] Tight junctions and paracellular fluid and ion transport in salivary glands
GH Zhang, LL Wu, GY Yu - Chin J Dent Res, 2013 - cjdr.cndent.com
Primary saliva is formed by salivary epithelial endpieces through two pathways, the
transcellular and the paracellular pathways. While the mechanisms of ion transport through …
transcellular and the paracellular pathways. While the mechanisms of ion transport through …
Exposure to a nonionic surfactant induces a response akin to heat-shock apoptosis in intestinal epithelial cells: implications for excipients safety
Amphipathic, nonionic, surfactants are widely used in pharmaceutical, food, and agricultural
industry to enhance product features; as pharmaceutical excipients, they are also aimed at …
industry to enhance product features; as pharmaceutical excipients, they are also aimed at …
Exploring tight junction alteration using double fluorescent probe combination of lanthanide complex with gold nanoclusters
X Wang, N Wang, L Yuan, N Li, J Wang, X Yang - Scientific reports, 2016 - nature.com
Tight junctions play a key role in restricting or regulating passage of liquids, ions and large
solutes through various biological barriers by the paracellular route. Changes in paracellular …
solutes through various biological barriers by the paracellular route. Changes in paracellular …