Genetic diversity of HIV in Africa: impact on diagnosis, treatment, vaccine development and trials

M Peeters, C Toure-Kane, JN Nkengasong - Aids, 2003 - journals.lww.com
AIDS is caused by two lentiviruses: HIV-1 and HIV-2 [1, 2]. AIDS was first recognized in the
1980s and is presently the leading cause of death in developing countries. Globally, it is …

Human immunodeficiency viruses in the developing world

M Essex - Advances in virus research, 1999 - Elsevier
Publisher Summary This chapter focuses on the effects of human immunodeficiency viruses
in the developing world. Acquired immunodeficiency syndrome (AIDS) has become a major …

High rate of recombination throughout the human immunodeficiency virus type 1 genome

AE Jetzt, H Yu, GJ Klarmann, Y Ron… - Journal of …, 2000 - Am Soc Microbiol
The diploid nature of human immunodeficiency virus type 1 (HIV-1) indicates that
recombination serves a central function in virus replication and evolution. Previously, while …

Comparing the ex vivo fitness of CCR5-tropic human immunodeficiency virus type 1 isolates of subtypes B and C

SC Ball, A Abraha, KR Collins, AJ Marozsan… - Journal of …, 2003 - Am Soc Microbiol
Continual human immunodeficiency virus type 1 (HIV-1) evolution and expansion within the
human population have led to unequal distribution of HIV-1 group M subtypes. In particular …

Different rates of disease progression of HIV type 1 infection in Tanzania based on infecting subtype

A Vasan, B Renjifo, E Hertzmark… - Clinical Infectious …, 2006 - academic.oup.com
Background. Many different subtypes of human immunodeficiency virus (HIV) type 1 have
been identified, particularly in sub-Saharan Africa. However, much remains unknown …

Preferential in-utero transmission of HIV-1 subtype C as compared to HIV-1 subtype A or D

B Renjifo, P Gilbert, B Chaplin, G Msamanga… - Aids, 2004 - journals.lww.com
Objective: To determine whether different HIV-1 genotypes present in a single cohort, in Dar
es Salaam, Tanzania, showed differences in timing for transmission from mothers to their …

[HTML][HTML] Recombinant HIV sequences: their role in the global epidemic

M Peeters - HIV sequence compendium, 2000 - hiv.lanl.gov
One of the major characteristics of the human immunodeficiency viruses (HIVs) is their
extremely high genetic variability. This extensive heterogeneity is the result of the high error …

Molecular cloning and phylogenetic analysis of human immunodeficiency virus type 1 subtype C: a set of 23 full-length clones from Botswana

VA Novitsky, MA Montano, MF McLane… - Journal of …, 1999 - Am Soc Microbiol
To better understand the virological aspect of the expanding AIDS epidemic in southern
Africa, a set of 23 near-full-length clones of human immunodeficiency virus type 1 (HIV-1) …

A specific subtype C of human immunodeficiency virus type 1 circulates in Brazil

MA Soares, T De Oliveira, RM Brindeiro, RS Diaz… - Aids, 2003 - journals.lww.com
Objective: To characterize the subtype C strains of HIV type 1 that circulate in Brazil,
especially those originated from the southern part of the country. Design and methods: One …

Identification of a major restriction in HIV-1 intersubtype recombination

MPS Chin, TD Rhodes, J Chen… - Proceedings of the …, 2005 - National Acad Sciences
Genetic recombination increases diversity in HIV-1 populations, thereby allowing variants to
escape from host immunity or antiviral therapies. In addition to the currently described nine …