Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells
in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that …

Summary Type 1 diabetes (T1D) is widely considered to result from the autoimmune
destruction of insulin-producing β cells. This concept has been a central tenet for decades of …

Type 1 diabetes mellitus (T1DM) results from the destruction of pancreatic β-cells that is
mediated by the immune system. Multiple genetic and environmental factors found in …

The polyamines—putrescine, spermidine, and spermine—are polycationic, low molecular
weight amines with cellular functions primarily related to mRNA translation and cell …

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a low platelet
count and an increased risk of bleeding. In addition to anti‐platelet autoantibodies, CD8+ T …

It has been proposed that unmethylated insulin promoter fragments in plasma derive
exclusively from β cells, reflect their recent demise, and can be used to assess β cell …

Diabetes mellitus is a multifactorial chronic metabolic disorder, characterized by altered
metabolism of macro-nutrients, such as fats, proteins, and carbohydrates. Diabetic …

Abstract Type 1 diabetes (T1D) is caused by aberrant activation of autoreactive T cells
specific for the islet beta cells. How islet‐specific T cells evade tolerance to become effector …

Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing beta cells,
found within the islets of Langerhans in the pancreas, are destroyed by islet-infiltrating T …

Abstract Purpose of Review The immunosuppressive agent cyclosporine was first reported
to lower daily insulin dose and improve glycemic control in patients with new-onset type 1 …