Acute myeloid leukemia (AML) is a malignant disorder of the bone marrow which is
characterized by the clonal expansion and differentiation arrest of myeloid progenitor cells …

ERK1 and ERK2 are related protein-serine/threonine kinases that participate in the Ras-Raf-
MEK-ERK signal transduction cascade. This cascade participates in the regulation of a large …

Gene therapy with LentiGlobin for sickle cell disease (bb1111, lovotibeglogene autotemcel)
consists of autologous transplantation of a patient's hematopoietic stem cells transduced …

T cells expressing anti-CD19 chimeric antigen receptors (CARs) can induce complete
remissions (CRs) of diffuse large B cell lymphoma (DLBCL). The long-term durability of …

Defects in apoptosis underpin both tumorigenesis and drug resistance, and because of
these defects chemotherapy often fails. Understanding the molecular events that contribute …

BACKGROUND Aberrant DNA methylation, which results in leukemogenesis, is frequent in
patients with myelodysplastic syndromes (MDS) and is a potential target for pharmacologic …

DNA methylation is an important regulator of gene transcription, and its role in
carcinogenesis has been a topic of considerable interest in the last few years. Alterations in …

Epigenetic changes such as DNA methylation act to regulate gene expression in normal
mammalian development. However, promoter hypermethylation also plays a major role in …

CPX-351 is a liposomal formulation of cytarabine: daunorubicin designed to deliver
synergistic drug ratios to leukemia cells. In this phase 2 study, newly diagnosed older acute …

Patients with secondary acute myeloid leukemia (AML) often escape inclusion in clinical
trials and thus, population‐based studies are crucial for its accurate characterization. In this …