Detrimental effects of COVID-19 in the brain and therapeutic options for long COVID: the role of Epstein–Barr virus and the gut–brain axis

K Hashimoto - Molecular Psychiatry, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in a serious public …

Emerging role of the host microbiome in neuropsychiatric disorders: overview and future directions

K Hashimoto - Molecular Psychiatry, 2023 - nature.com
The human body harbors a diverse ecosystem of microorganisms, including bacteria,
viruses, and fungi, collectively known as the microbiota. Current research is increasingly …

[HTML][HTML] Key role of the gut–microbiota–brain axis via the subdiaphragmatic vagus nerve in demyelination of the cuprizone-treated mouse brain

X Wang, A Eguchi, Y Yang, L Chang, X Wan… - Neurobiology of …, 2023 - Elsevier
Multiple sclerosis (MS) is the most common demyelinating disease that attacks the central
nervous system. Dietary intake of cuprizone (CPZ) produces demyelination resembling that …

Neuroinflammation through the vagus nerve-dependent gut–microbiota–brain axis in treatment-resistant depression

K Hashimoto - Progress in Brain Research, 2023 - Elsevier
Neuroinflammation plays a key role in the pathogenesis of major depressive disorder
(MDD), including treatment-resistant depression (TRD). Patients with TRD have higher …

The gut-brain axis and cognitive control: A role for the vagus nerve

L Décarie-Spain, AMR Hayes, LT Lauer… - Seminars in Cell & …, 2024 - Elsevier
Survival requires the integration of external information and interoceptive cues to effectively
guide advantageous behaviors, particularly foraging and other behaviors that promote …

The role of the gut–microbiota–brain axis via the subdiaphragmatic vagus nerve in chronic inflammatory pain and comorbid spatial working memory impairment in …

C Yue, W Luan, H Gu, D Qiu, X Ding, P Liu… - Journal of Psychiatric …, 2023 - Elsevier
Chronic inflammatory pain (CIP) is a common public medical problem, often accompanied
by memory impairment. However, the mechanisms underlying CIP and comorbid memory …

Impact of broad-spectrum antibiotics on the gut–microbiota–spleen–brain axis

X Wan, A Eguchi, A Sakamoto, Y Fujita, Y Yang… - Brain, Behavior, & …, 2023 - Elsevier
The spleen is a key immune-related organ that plays a role in communication between the
brain and the immune system through the brain–spleen axis and brain–gut–microbiota axis …

Depression-like phenotypes in mice with hepatic ischemia/reperfusion injury: A role of gut–microbiota–liver–brain axis via vagus nerve

Y Yang, A Eguchi, X Wan, C Mori… - Journal of Affective …, 2024 - Elsevier
Depression is a frequent symptom in patients with chronic liver disease; however, the
mechanisms underlying this association remain unclear. Dysbiosis of gut microbiota plays a …

Polygonum sibiricum polysaccharides exert the antidepressant‐like effects in chronic unpredictable mild stress‐induced depressive mice by modulating microbiota …

Y Zhang, Y Sun, Y Liu, J Liu, J Sun, X Liu… - Phytotherapy …, 2023 - Wiley Online Library
Polygonum sibiricum polysaccharides (PSP) are one of the main active components of
Polygonatum sibiricum, which is a traditional Chinese medicine with food and drug …

Short-chain fatty acids in the microbiota–gut–brain axis: role in neurodegenerative disorders and viral infections

A Majumdar, IP Siva Venkatesh… - ACS Chemical …, 2023 - ACS Publications
The gut–brain axis (GBA) is the umbrella term to include all bidirectional communication
between the brain and gastrointestinal (GI) tract in the mammalian body. Evidence from over …