The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

In the past decade, numerous studies have demonstrated the close relationship between gut
microbiota and the occurrence and development of Alzheimer's disease (AD). However, the …

Tauroursodeoxycholic acid (TUDCA) is a naturally occurring hydrophilic bile acid that has
been used for centuries in Chinese medicine. Chemically, TUDCA is a taurine conjugate of …

Bile acids are signalling hormones involved in the regulation of several metabolic pathways.
The ability of bile acids to bind and signal through their receptors is modulated by the gut …

Bile acids, mainly ursodeoxycholic acid (UDCA) and its conjugated species
glycoursodeoxycholic acid (GUDCA) and tauroursodeoxycholic acid (TUDCA) have long …

Background The FDA-approved small-molecule drug ibrutinib is an effective targeted
therapy for patients with chronic lymphocytic leukemia (CLL). Ibrutinib inhibits Bruton's …

The intestinal microbiota plays an important role in the pathophysiology of depression. As
determined, the microbiota influences the shaping and modulation of the functioning of the …

Bile acids are steroid acids found in the bile of mammals. The bile acid conjugate
tauroursodeoxycholic acid (TUDCA) is neuroprotective in different animal models of stroke …

Background Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid derivative, which
has been demonstrated to have neuroprotective effects in different neurological disease …

Certain endogenous bile acids have been proposed as potential therapies for ameliorating
Alzheimer's disease (AD) but their role, if any, in the pathophysiology of this disease is not …