Most patients survive acute myocardial infarction (MI). Yet this encouraging development
has certain drawbacks: heart failure (HF) prevalence is increasing and patients affected tend …

Despite the success of renin-angiotensin system (RAS) blockade by angiotensin-converting
enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT1R) blockers, current …

Gut hormones orchestrate pivotal physiological processes in multiple metabolically active
tissues, including the pancreas, liver, adipose tissue, gut and central nervous system …

Rises in local neural activity trigger local increases of cerebral blood flow, which is essential
to match local energy demands. However, the specific location of microvascular flow control …

The discovery of soluble GC (sGC) stimulators and sGC activators provided valuable tools to
elucidate NO–sGC signalling and opened novel pharmacological opportunities for …

Abstract When Furchgott, Murad, and Ignarro were honored with the Nobel prize for the
identification of nitric oxide (NO) in 1998, the therapeutic implications of this discovery could …

Hypertension affects over 1.2 billion individuals worldwide and has become the most critical
and expensive public health problem. Hypertension is a multifactorial disease involving …

Cyclic guanosine monophosphate (cGMP) is a unique second messenger molecule formed
in different cell types and tissues. cGMP targets a variety of downstream effector molecules …

The discovery of the heart as an endocrine organ resulted in a remarkable recognition of the
natriuretic peptide system (NPS). Specifically, research has established the production of …

Cachexia is associated with poor prognosis in chronic heart failure patients, but the
underlying mechanisms of cachexia triggered disease progression remain poorly …