[HTML][HTML] The protease corin regulates electrolyte homeostasis in eccrine sweat glands

M He, T Zhou, Y Niu, W Feng, X Gu, W Xu, S Zhang… - PLoS …, 2021 - journals.plos.org
Sweating is a basic skin function in body temperature control. In sweat glands, salt excretion
and reabsorption are regulated to avoid electrolyte imbalance. To date, the mechanism …

[HTML][HTML] Roles of natriuretic peptides and the significance of neprilysin in cardiovascular diseases

H Nakagawa, Y Saito - Biology, 2022 - mdpi.com
Simple Summary The endocrine effects of atrial natriuretic peptide (ANP) and brain
natriuretic peptide (BNP) in the vasculature, and the autocrine effects of ANP and BNP in …

[HTML][HTML] Prevention of guanylyl cyclase–B dephosphorylation rescues achondroplastic dwarfism

BM Wagner, JW Robinson, YW Lin, YC Lee, N Kaci… - JCI insight, 2021 - ncbi.nlm.nih.gov
Activating mutations in the fibroblast growth factor receptor 3 (FGFR3) or inactivating
mutations in guanylyl cyclase–B (GC-B), also known as NPR-B or Npr2, cause short-limbed …

[HTML][HTML] Natriuretic Peptide Signaling in Uterine Biology and Preeclampsia

Q Wu - International Journal of Molecular Sciences, 2023 - mdpi.com
Endometrial decidualization is a uterine process essential for spiral artery remodeling,
embryo implantation, and trophoblast invasion. Defects in endometrial decidualization and …

Qingchang Wenzhong Decoction ameliorates intestinal inflammation and intestinal barrier dysfunction in ulcerative colitis via the GC-C signaling pathway

Y Zhang, J Li, X Han, H Jiang, J Wang… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Ulcerative colitis (UC) is an idiopathic, chronic
inflammatory disorder of the colonic mucosa, accompanied with abdominal pain, and bloody …

Targeting the paracrine hormone-dependent guanylate cyclase/cGMP/phosphodiesterases signaling pathway for colorectal cancer prevention

NS Yarla, H Gali, G Pathuri, S Smriti, M Farooqui… - Seminars in cancer …, 2019 - Elsevier
Colorectal cancer (CRC) is one of the leading causes of cancer related-deaths. The risk of
development of CRC is complex and multifactorial, and includes disruption of homeostasis …

Long-term blood pressure lowering and cGMP-activating actions of the novel ANP analog MANP

Y Chen, JJ Schaefer, SR Iyer… - American Journal …, 2020 - journals.physiology.org
Based on the cardiac hormone atrial natriuretic peptide (ANP) and its seminal role in blood
pressure (BP) homeostasis, we investigated the chronic BP lowering actions of a novel ANP …

Integrated analysis of oncogenic networks in colorectal cancer identifies GUCA2A as a molecular marker

H Zhang, Y Du, Z Wang, R Lou, J Wu… - Biochemistry research …, 2019 - Wiley Online Library
Colorectal cancer (CRC) is one of the most common and deadly malignancies in the world.
In China, the morbidity rate of CRC has increased during the period 2000 to 2011 …

[HTML][HTML] Intestinal immunoregulation: lessons from human mendelian diseases

F Charbit-Henrion, M Parlato, G Malamut… - Mucosal …, 2021 - Elsevier
The mechanisms that maintain intestinal homeostasis despite constant exposure of the gut
surface to multiple environmental antigens and to billions of microbes have been scrutinized …

[HTML][HTML] Natriuretic peptide-based novel therapeutics: long journeys of drug developments optimized for disease states

T Ichiki, A Jinno, Y Tsuji - Biology, 2022 - mdpi.com
Simple Summary Natriuretic peptides are endogenous hormones produced in the heart and
vascular endothelium, and they enable cardiorenal protective actions or bone growth via …