IL-6 activates various cell types carrying the membrane bound IL-6R (classical IL-6
signaling) as well as IL-6R− gp130+ cells via the soluble IL-6R (IL-6 trans-signaling). IL-6 …

Abstract Interleukin (IL)-6 is a pleiotropic cytokine that not only affects the immune system,
but also acts in other biological systems and many physiological events in various organs. In …

Background & Aims: We set out to test the hypothesis that irritable bowel syndrome (IBS) is
characterized by an augmented cellular immune response with enhanced production of …

Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases
(IBDs) occurring in the gut of genetically susceptible individuals independent of a specific …

Background and Aims: Ulcerative colitis (UC) is a chronic relapsing inflammatory bowel
disease. We aimed to assess whether clinical, biological, and histologic parameters in …

Cytokines play a central role in the modulation of the intestinal immune system. They are
produced by lymphocytes (especially T cells of the Th1 and Th2 phenotypes), monocytes …

Previous studies reported that L-fucose had anti-inflammatory effects in respiratory and
cutaneous system. However, the effect of L-fucose on colitis and the underlying mechanism …

BACKGROUND & AIMS: Acute gastroenteritis is the strongest risk factor for irritable bowel
syndrome (IBS). In May 2000,> 2300 residents of Walkerton, Ontario, developed …

OBJECTIVES: Immune activation may have an important pathogenic role in the irritable
bowel syndrome (IBS). While little is known about immunologic function in functional …

Matrine is a naturally occurring quinolizidine alkaloid with various bioactivities. However,
little is known of its function on ulcerative colitis (UC). Here, we investigated the effect and …