Human aging is currently defined as a physiological decline of biological functions in the
body with a continual adaptation to internal and external damaging. The endocrine system …

Human growth hormone (GH) is a classical pituitary endocrine hormone that is essential for
normal postnatal growth and has pleiotropic effects across multiple physiological systems …

Background Epigenetic clocks can track both chronological age (cAge) and biological age
(bAge). The latter is typically defined by physiological biomarkers and risk of adverse health …

Although aging is a conserved phenomenon across evolutionary distant species, aspects of
the aging process have been found to differ between males and females of the same …

Role of growth hormone (GH) in mammalian aging is actively explored in clinical,
epidemiological, and experimental studies. The age-related decline in GH levels is variously …

Recently, there has been an increase in the incidence of malignant tumors among the older
population. Moreover, there is an association between aging and cancer. During the …

Age-related cerebrovascular pathologies, ranging from cerebromicrovascular functional and
structural alterations to large vessel atherosclerosis, promote the genesis of vascular …

Experimental, clinical, and epidemiological findings support the concept of developmental
origins of health and disease (DOHAD), suggesting that early-life hormonal influences …

Lifespan varies greatly across the tree of life. Of the various explanations for this
phenomenon, those that involve trade-offs between reproduction and longevity have gained …

Pedomorphy, maintenance of juvenile traits throughout life, is most pronounced in
extraordinarily long-lived naked mole-rats. Many of these traits (eg, slow growth rates, low …