Leishmaniasis is a neglected tropical disease that affects people living in tropical and
subtropical areas of the world. There are few therapeutic options for treating this infectious …

Current treatment guidelines for leishmaniasis is based on chemotherapy with drugs that
show a set of limitations such as high cost, toxicity, difficult route of administration, and lack …

Leishmaniasis and Chagas disease are infectious diseases caused by parasite Leishmania
sp. and Trypanosoma cruzi, respectively, and are included among the most neglected …

Leishmaniasis and Chagas are diseases caused by parasitic protozoans that affect the
poorest population in the World, causing a high mortality and morbidity. As a result of highly …

Deciphering the ecological roles of plant secondary metabolites requires integrative studies
that assess both the allocation patterns of compounds and their bioactivity in ecological …

Piper eriopodon is one of the Piper species found in the Sierra Nevada de Santa Marta, and
the species has been reported with different compositions of their essential oils (EO). In this …

X-linked inhibitor of apoptosis protein (XIAP) is an emerging crucial therapeutic target in
cancer. We report on the discovery and characterisation of small organic molecules from …

The essential oils from leaves of Piper malacophyllum (Piperaceae) showed to be mainly
composed by two alkenylphenol derivatives: gibbilimbols A and B. After isolation and …

Trypanosoma cruzi is the causing agent of Chagas disease, a parasitic infection without
efficient treatment for chronic patients. Despite the efforts, no new drugs have been …

Background Chagas disease and leishmaniasis affect a significant portion of the Latin
American population and still lack efficient treatments. In this context, natural products …