Resistance to therapeutic treatment and metastatic progression jointly determine a fatal
outcome of cancer. Cancer metastasis and therapeutic resistance are traditionally studied as …

Collective cancer invasion with leader–follower organization is increasingly recognized as a
predominant mechanism in the metastatic cascade. Leader cells support cancer invasion by …

During cancer therapy, phagocytic clearance of dead cells plays a vital role in immune
homeostasis. The nonapoptotic form of cell death, ferroptosis, exhibits extraordinary …

Magnetic resonance elastography (MRE) is a versatile imaging technique for mapping the
viscoelastic properties of soft biological tissues. It has been widely used to detect liver …

Three-dimensional hydrogel-based organ-like cultures can be applied to study
development, regeneration, and disease in vitro. However, the control of engineered …

Tissues consist of cells and their surrounding extracellular matrix (ECM). Cell–ECM
interactions play crucial roles in embryonic development, differentiation, tissue remodeling …

Pathological morphological changes in tumor tissue enable collective cancer cell
unjamming, a cellular motility transition. However, fundamental questions remain: Is …

The epithelial-to-mesenchymal transition (EMT) and the unjamming transition (UJT) each
comprises a gateway to cellular migration, plasticity and remodeling, but the extent to which …

Tissue, cell, and nucleus morphology change during tumor progression. In 2D confluent cell
cultures, different tissue states, such as fluid (unjammed) and solid (jammed), are correlated …

Tissue and organ development during embryogenesis relies on the collective and
coordinated action of many cells. Recent studies have revealed that tissue material …