The mesolimbic hypothesis has been a central dogma of schizophrenia for decades,
positing that aberrant functioning of midbrain dopamine projections to limbic regions causes …

Dopamine-releasing neurons of the ventral tegmental area (VTA) have central roles in
reward-related and goal-directed behaviours. VTA dopamine-releasing neurons are …

Striatal dopamine and acetylcholine are essential for the selection and reinforcement of
motor actions and decision-making. In vitro studies have revealed an intrastriatal circuit in …

External rewards such as food and money are potent modifiers of behaviour,. Pioneering
studies established that these salient sensory stimuli briefly interrupt the tonic discharge of …

Environmental stimuli and objects, including rewards, are often processed sequentially in
the brain. Recent work suggests that the phasic dopamine reward prediction-error response …

Neurons in the mammalian brain are not limited to releasing a single neurotransmitter but
often release multiple neurotransmitters onto postsynaptic cells. Here, we review recent …

The long-range GABAergic input from the ventral tegmental area (VTA) to the nucleus
accumbens (NAc) is relatively understudied, and therefore its role in reward processing has …

The mesocorticolimbic pathway is canonically known as the" reward pathway." Embedded
within the center of this circuit is the striatum, a massive and complex network hub that …

Striatal dopamine encodes reward, with recent work showing that dopamine release occurs
in spatiotemporal waves. However, the mechanism of dopamine waves is unknown. Here …

In light of the clinical evidence implicating dopamine in schizophrenia and the prominent
hypotheses put forth regarding alterations in dopaminergic transmission in this disease …