Stimulator of interferon genes (STING) is an endoplasmic-reticulum resident protein, playing
essential roles in immune responses against microbial infections. However, over-activation …

The intestinal mucosa is constantly exposed to commensal microbes, opportunistic
pathogens, toxins, luminal components and other environmental stimuli. The intestinal …

Membrane contact sites (MCSs) link organelles to coordinate cellular functions across space
and time. Although viruses remodel organelles for their replication cycles, MCSs remain …

Extensive studies demonstrate the importance of the STING1 (also known as STING) protein
as a signaling hub that coordinates immune and autophagic responses to ectopic DNA in …

Human cytomegalovirus (HCMV) is a widespread pathogen that in immunocompromised
hosts can cause life-threatening disease. Studying HCMV-exposed monocyte-derived …

Despite only comprising half of all known viral species, RNA viruses are disproportionately
responsible for many of the worst epidemics in human history, including outbreaks of …

Since the discovery that cGAS/STING recognizes endogenous DNA released from dying
cancer cells and induces type I interferon and antitumor T cell responses, efforts to …

Human cytomegalovirus (HCMV) is a ubiquitous human pathogen that can cause severe
disease in immunocompromised individuals, transplant recipients, and to the developing …

YES-associated protein (YAP), a critical actor of the mammalian Hippo signaling pathway
involved in diverse biological events, has gained increased recognition as a cellular factor …

Stimulator of interferon response cGAMP interactor 1 (STING1), also known as TMEM173, is
an immune adaptor protein that governs signal crosstalk that is implicated in many …