The translational neural circuitry of anxiety

OJ Robinson, AC Pike, B Cornwell… - Journal of Neurology …, 2019 - jnnp.bmj.com
Anxiety is an adaptive response that promotes harm avoidance, but at the same time
excessive anxiety constitutes the most common psychiatric complaint. Moreover, current …

Rapid cortical plasticity supports long-term memory formation

M Hebscher, E Wing, J Ryan, A Gilboa - Trends in Cognitive Sciences, 2019 - cell.com
The standard systems consolidation account posits that recently formed memories are
initially dependent on the hippocampus and only gradually become instantiated in …

[HTML][HTML] A neurocognitive perspective on the forms and functions of autobiographical memory retrieval

S Sheldon, C Fenerci, L Gurguryan - Frontiers in systems …, 2019 - frontiersin.org
Autobiographical memory retrieval involves constructing mental representations of personal
past episodes by associating together an array of details related to the retrieved event. This …

Glucocorticoids and hippocampal structure and function in PTSD

PR Szeszko, A Lehrner, R Yehuda - Harvard review of psychiatry, 2018 - journals.lww.com
This review examines the putative link between glucocorticoid and hippocampal
abnormalities in posttraumatic stress disorder (PTSD). Increased glucocorticoid receptor …

Paraventricular thalamus controls behavior during motivational conflict

EA Choi, P Jean-Richard-dit-Bressel… - Journal of …, 2019 - Soc Neuroscience
Decision-making often involves motivational conflict because of the competing demands of
approach and avoidance for a common resource: behavior. This conflict must be resolved as …

Quantifying aberrant approach-avoidance conflict in psychopathology: A review of computational approaches

AM Letkiewicz, HC Kottler, SA Shankman… - Neuroscience & …, 2023 - Elsevier
Making effective decisions during approach-avoidance conflict is critical in daily life.
Aberrant decision-making during approach-avoidance conflict is evident in a range of …

[HTML][HTML] Ventral hippocampal CA1 and CA3 differentially mediate learned approach-avoidance conflict processing

A Schumacher, FR Villaruel, A Ussling, S Riaz… - Current Biology, 2018 - cell.com
Approach-avoidance conflict arises when an animal encounters a stimulus that is associated
simultaneously with positive and negative valences [1]. The effective resolution of approach …

Why we need nonhuman primates to study the role of ventromedial prefrontal cortex in the regulation of threat-and reward-elicited responses

AC Roberts, HF Clarke - Proceedings of the National …, 2019 - National Acad Sciences
The ventromedial prefrontal cortex (vmPFC) is consistently implicated in the cognitive and
emotional symptoms of many psychiatric disorders, but the causal mechanisms of its …

Cingulate cortex in the three limbic subsystems

BA Vogt - Handbook of clinical neurology, 2019 - Elsevier
Abstract Broca's (1878) definition of the limbic lobe referred to its being located at the edge
of the cerebral cortex, and Papez (1937) and MacLean (1990) welded a series of medial …

[HTML][HTML] The 'Jekyll and Hyde'of gluconeogenesis: early life adversity, later life stress, and metabolic disturbances

SV Seal, JD Turner - International Journal of Molecular Sciences, 2021 - mdpi.com
The physiological response to a psychological stressor broadly impacts energy metabolism.
Inversely, changes in energy availability affect the physiological response to the stressor in …