Over the past two decades, research has identified extrasynaptic GABA A receptor
populations that enable neurons to sense the low ambient GABA concentrations present in …

Introduction: The first two alpha2delta ligands–gabapentin (GBP) and pregabalin (PGB)–
were initially synthesized as antiepileptics; however, they were later also found to be useful …

A site-selective defluorinative sp3 C–H alkylation of secondary amides that rapidly and
reliably incorporates gem-difluoroalkene motifs into previously unfunctionalized sp3 sites is …

Abstract Carbon–carbon (C–C) bond formation is paramount in the synthesis of biologically
relevant molecules, modern synthetic materials and commodity chemicals such as fuels and …

Introduction: Anxiety disorders are among the most prevalent and disabling psychiatric
disorders in the United States and worldwide. Basic research has provided critical insights …

Pregabalin is an antagonist of voltage gated Ca2+ channels and specifically binds to alpha-
2-delta subunit to produce antiepileptic and analgesic actions. It successfully alleviates the …

Background Pain during pregnancy is common, and its management is complex. Certain
analgesics may increase the risk for adverse fetal and pregnancy outcomes, while poorly …

Inspired by advances in our understanding of biological processes, new reactions
employing organic molecules as catalysts have grown significantly over the last two …

Pregabalin (Lyrica®), a well established anxiolytic agent, has been approved in the EU for
the treatment of generalized anxiety disorder (GAD) in adults. It has a distinct mechanism of …

Neuropathic and psychogenic itch are two entities that have not been well studied.
Neuropathic itch is related to pathology located at any point along the afferent pathway of …