Background Functional constipation is a common functional bowel disorder in the
community, which has a varying prevalence across cross-sectional surveys. We did a …

Background: The prevalence of constipation in Japan is estimated to be 2–5%. Constipation
is a disease found in older adults. In particular, Japan is an aging society, with 65% of men …

The pathophysiology of fecal incontinence (FI) is often considered to primarily depend on
disturbed mechanisms of faecal containment. Barrier mechanisms such as the anal …

Objectives: Chronic constipation is a common gastrointestinal disorder, and management is
crucial. Computed tomography (CT) is useful for evaluating rectal fecal mass but limited …

Introduction Chronic idiopathic constipation (CIC) is characterized by infrequent bowel
movements and hard stools lasting for at least three months or longer. This disease affects 8 …

Objective High rectal sensory thresholds (RSTs) are associated with chronic constipation
(CC), especially in older patients. Bile acids (BAs) affect the RSTs of healthy individuals …

Background It is unclear which laxatives are appropriate to prevent opioid-induced
constipation (OIC). This study will evaluate whether prophylactic use of naldemedine …

Introduction Chronic constipation (CC) is a functional disorder that negatively impacts the
quality of life of patients. This is a protocol for a multicentre, 12-week, randomised, double …

Background Approximately 60% of patients with chronic constipation (CC) have a
significantly higher rate of loss of defecation desire (LODD). Bile acids are expected to have …

METHODS: A prospective study of 43 healthy adult women and 140 consecutive adult
women attending a tertiary center for investigation of CC. All participants completed a 5-day …