In metastasis, cancer cells travel around the circulation to colonize distant sites. Due to the
rarity of these events, the immediate fates of metastasizing tumor cells (mTCs) are poorly …

Bridging the gap between genetic variations, environmental determinants, and phenotypic
outcomes is critical for supporting clinical diagnosis and understanding mechanisms of …

Single-cell RNA-sequencing (scRNA-seq) is one of the most used single-cell omics in recent
decades. The exponential growth of single-cell data has immense potential for large-scale …

ORFanage is a system designed to assign open reading frames (ORFs) to known and novel
gene transcripts while maximizing similarity to annotated proteins. The primary intended use …

Background Eukaryotic ribosomes are widely presumed to scan mRNA for the AUG codon to
initiate translation in a strictly 5′–3′ movement (ie, strictly unidirectional scanning model) …

Motivation A recurring challenge in interpreting genomic data is the assessment of results in
the context of existing reference databases. With the increasing number of command line …

Contamination of genomes is an increasingly recognized problem affecting several
downstream applications, from comparative evolutionary genomics to metagenomics. Here …

With the exponential growth of multi-omics data, its integration and utilization have brought
unprecedented opportunities for the interpretation of gene regulation mechanisms and the …

Understanding the impacts of selection pressures influencing modern-day genomic diversity
is a major goal of evolutionary genomics. In particular, the contribution of selective sweeps …

The subcellular localization of long non-coding RNAs (lncRNAs) is crucial for understanding
lncRNA functions. Most of existing lncRNA subcellular localization prediction methods use k …