[HTML][HTML] Recent advances in carrier mediated nose-to-brain delivery of pharmaceutics

V Bourganis, O Kammona, A Alexopoulos… - European Journal of …, 2018 - Elsevier
Central nervous system (CNS) disorders (eg, multiple sclerosis, Alzheimer's disease, etc.)
represent a growing public health issue, primarily due to the increased life expectancy and …

Airflow and particle transport in the human respiratory system

C Kleinstreuer, Z Zhang - Annual review of fluid mechanics, 2010 - annualreviews.org
Airflows in the nasal cavities and oral airways are rather complex, possibly featuring a
transition to turbulent jet-like flow, recirculating flow, Dean's flow, vortical flows, large …

Host-to-host airborne transmission as a multiphase flow problem for science-based social distance guidelines

S Balachandar, S Zaleski, A Soldati, G Ahmadi… - International Journal of …, 2020 - Elsevier
The COVID-19 pandemic has strikingly demonstrated how important it is to develop
fundamental knowledge related to the generation, transport and inhalation of pathogen …

Study on the coal dust deposition fraction and site in the upper respiratory tract under different particle sizes and labor intensities

Y Cheng, H Yu, S Xie, J Zhao, Y Ye - Science of The Total Environment, 2023 - Elsevier
In order to study the dust exposure amount and coal dust deposition rule of coal miners
under different labor intensity in coal mine environment, an airflow-particle two-phase …

[图书][B] Multiphase flow handbook

E Michaelides, CT Crowe, JD Schwarzkopf - 2016 - books.google.com
The Multiphase Flow Handbook, Second Edition is a thoroughly updated and reorganized
revision of the late Clayton Crowe's work, and provides a detailed look at the basic concepts …

The fluid dynamics of canine olfaction: unique nasal airflow patterns as an explanation of macrosmia

BA Craven, EG Paterson… - Journal of the Royal …, 2010 - royalsocietypublishing.org
The canine nasal cavity contains hundreds of millions of sensory neurons, located in the
olfactory epithelium that lines convoluted nasal turbinates recessed in the rear of the nose …

Mechanics of airflow in the human nasal airways

DJ Doorly, DJ Taylor, RC Schroter - Respiratory physiology & neurobiology, 2008 - Elsevier
The mechanics of airflow in the human nasal airways is reviewed, drawing on the findings of
experimental and computational model studies. Modelling inevitably requires simplifications …

Targeted drug-aerosol delivery in the human respiratory system

C Kleinstreuer, Z Zhang… - Annu. Rev. Biomed. Eng., 2008 - annualreviews.org
Inhalation of drug aerosols is a modern pathway to combat lung diseases. It is also
becoming the preferred route for insulin delivery, pain management, cancer therapy, and …

Olfactory deposition of inhaled nanoparticles in humans

GJM Garcia, JD Schroeter, JS Kimbell - Inhalation toxicology, 2015 - Taylor & Francis
Context: Inhaled nanoparticles can migrate to the brain via the olfactory bulb, as
demonstrated in experiments in several animal species. This route of exposure may be the …

In silico models of aerosol delivery to the respiratory tract—development and applications

PW Longest, LT Holbrook - Advanced drug delivery reviews, 2012 - Elsevier
This review discusses the application of computational models to simulate the transport and
deposition of inhaled pharmaceutical aerosols from the site of particle or droplet formation to …