Nonalcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD) are the
leading causes of chronic liver disease worldwide. NAFLD and ALD share …

Type 2 diabetes mellitus (T2DM) is characterized by tissue-specific insulin resistance and
pancreatic β-cell dysfunction, which result from the interplay of local abnormalities within …

Mitochondrial pyruvate carrier 1 regulates fatty acid syntha... : Hepatology Mitochondrial pyruvate
carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty …

Together with the global rise in obesity and metabolic syndrome, the prevalence of
individuals who suffer from nonalcoholic fatty liver disease (NAFLD) has risen dramatically …

Metabolic dysfunction-associated fatty liver disease (MAFLD) is among the most widespread
metabolic disease globally, and its associated complications including insulin resistance …

The burden of chronic liver disease is rising substantially worldwide. Fibrosis, characterized
by excessive deposition of extracellular matrix proteins, is the common pathway leading to …

Obesity, diabetes mellitus (mostly type 2), and COVID-19 show mutual interactions because
they are not only risk factors for both acute and chronic COVID-19 manifestations, but also …

Type 2 diabetes mellitus is often associated with cirrhosis as comorbidities, acute illness,
medications, and other conditions profoundly alter glucose metabolism. Both conditions are …

Background Disturbed hepatic energy metabolism contributes to non-alcoholic fatty liver
(NAFLD), but the development of changes over time and obesity-or diabetes-related …

Pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (KGDH) are vital entry
points for monosaccharides and amino acids into the Krebs cycle and thus integral for …