Liver ischaemia–reperfusion injury (LIRI), a local sterile inflammatory response driven by
innate immunity, is one of the primary causes of early organ dysfunction and failure after …

Fibronectin structure and composition regulate contextual cell signaling. Recent advances
have been made in understanding fibronectin and its role in tissue organization and repair …

The release of growth factors, cytokines and extracellular matrix modifiers by activated
platelets is an important step in the process of healthy wound healing. Extracellular vesicles …

Wound healing is an essential process to restore tissue integrity after trauma. Large skin
wounds such as burns often heal with hypertrophic scarring and contractures, resulting in …

Beyond their role in hemostasis and thrombosis, platelets are increasingly recognized as
key regulators of the inflammatory response under sterile and infectious conditions. Both …

Tissue repair is a very complex event and involves a continuously orchestrated sequence of
signals and responses from platelets, fibroblasts, epithelial, endothelial and immune cells …

Bladder cancer is a prevalent but currently understudied cancer type and patient outcomes
are poor when it progresses to the muscle-invasive stage. Current research in bladder …

Platelets play important roles in thrombosis-dependent obstructive cardiovascular diseases.
In addition, it has now become evident that platelets also participate in the earliest stages of …

Cardiovascular disease remains the main cause of death worldwide. For this reason,
strategies for the primary prevention of atherosclerosis and atherosclerosis-related …

Beyond their fundamental role in hemostasis, platelets importantly contribute to other
processes aimed at maintaining homeostasis. Indeed, platelets are a natural source of …