The nucleolus is the major site for synthesis of ribosomes, complex molecular machines that
are responsible for protein synthesis. A wealth of research over the past 20 years has clearly …

The biosynthesis of ribosomes is a complex process that requires the coordinated action of
many factors and a huge energy investment from the cell. Ribosomes are essential for …

The p53 tumor suppressor is a key transcription factor regulating cellular pathways such as
DNA repair, cell cycle, apoptosis, angiogenesis, and senescence. It acts as an important …

A veritable explosion of primary research papers within the past 10 years focuses on
nucleolar and ribosomal stress, and for good reason: with ribosome biosynthesis …

NPM1 is a crucial gene to consider in the context of the genetics and biology of cancer.
NPM1 is frequently overexpressed, mutated, rearranged and deleted in human cancer …

The nucleophosmin (NPM1) gene encodes for a multifunctional nucleocytoplasmic shuttling
protein that is localized mainly in the nucleolus. NPM1 mutations occur in 50% to 60% of …

At a first glance, ribosome biogenesis and chromatin remodeling are quite different
processes, but they share a common problem involving interactions between charged …

Although the importance of the ARF tumor suppressor in p53 regulation is well established,
numerous studies indicate that ARF also suppresses cell growth in a p53/Mdm2 …

Mammalian cells that sustain oncogenic insults can invoke defensive programmes that
either halt their division or trigger their apoptosis, but these countermeasures must be finely …

Nucleophosmin (also known as NPM, B23, NO38) is a nucleolar protein directly implicated
in cancer pathogenesis, as the NPM1 gene is found mutated and rearranged in a number of …