Clinical trial in a dish: using patient-derived induced pluripotent stem cells to identify risks of drug-induced cardiotoxicity
Drug-induced cardiotoxicity is a significant clinical issue, with many drugs in the market
being labeled with warnings on cardiovascular adverse effects. Treatments are often …
being labeled with warnings on cardiovascular adverse effects. Treatments are often …
Ebselen, Iron Uptake Inhibitor, Alleviates Iron Overload‐Induced Senescence‐Like Neuronal Cells SH‐SY5Y via Suppressing the mTORC1 Signaling Pathway
Increasing evidence highlights that excessive iron accumulation in the brain plays a vital
role in neuronal senescence and is implicated in the pathogenesis of age‐related …
role in neuronal senescence and is implicated in the pathogenesis of age‐related …
An alternative mechanism of subcellular iron uptake deficiency in cardiomyocytes
Background: Systemic defects in intestinal iron absorption, circulation, and retention cause
iron deficiency in 50% of patients with heart failure. Defective subcellular iron uptake …
iron deficiency in 50% of patients with heart failure. Defective subcellular iron uptake …
[HTML][HTML] Building multi-dimensional induced pluripotent stem cells-based model platforms to assess cardiotoxicity in cancer therapies
Cardiovascular disease (CVD) complications have contributed significantly toward poor
survival of cancer patients worldwide. These complications that result in myocardial and …
survival of cancer patients worldwide. These complications that result in myocardial and …
Ebselen restores peri-implantitis-induced osteogenic inhibition via suppressing BMSCs ferroptosis
Z Huang, G Chen, H Wu, X Huang, R Xu… - Experimental Cell …, 2023 - Elsevier
It is hard to reconstruct bone defects in peri-implantitis due to osteogenesis inhibited by
excessive reactive oxygen species (ROS). Ferroptosis, a recently identified regulated cell …
excessive reactive oxygen species (ROS). Ferroptosis, a recently identified regulated cell …
[HTML][HTML] Clinical and molecular aspects of iron metabolism in failing myocytes
B Kozłowska, B Sochanowicz, L Kraj, M Palusińska… - Life, 2022 - mdpi.com
Heart failure (HF) is a common disease that causes significant limitations on the organism's
capacity and, in extreme cases, leads to death. Clinically, iron deficiency (ID) plays an …
capacity and, in extreme cases, leads to death. Clinically, iron deficiency (ID) plays an …
[HTML][HTML] Cardiac iron metabolism during aging–Role of inflammation and proteolysis
S Walter, C Mertens, MU Muckenthaler, C Ott - Mechanisms of ageing and …, 2023 - Elsevier
Iron is the most abundant trace element in the human body. Since iron can switch between
its 2-valent and 3-valent form it is essential in various physiological processes such as …
its 2-valent and 3-valent form it is essential in various physiological processes such as …
Death-seq identifies regulators of cell death and senolytic therapies
A Colville, JY Liu, C Rodriguez-Mateo, S Thomas… - Cell Metabolism, 2023 - cell.com
Selectively ablating damaged cells is an evolving therapeutic approach for age-related
disease. Current methods for genome-wide screens to identify genes whose deletion might …
disease. Current methods for genome-wide screens to identify genes whose deletion might …
Chronic ethanol exposure induces deleterious changes in cardiomyocytes derived from human induced pluripotent stem cells
Chronic alcohol consumption in adults can induce cardiomyopathy, arrhythmias, and heart
failure. In newborns, prenatal alcohol exposure can increase the risk of congenital heart …
failure. In newborns, prenatal alcohol exposure can increase the risk of congenital heart …
[HTML][HTML] Gaining insight into mitochondrial genetic variation and downstream pathophysiology: What can i (pscs) do?
Mitochondria are specialized organelles involved in energy production that have retained
their own genome throughout evolutionary history. The mitochondrial genome (mtDNA) is …
their own genome throughout evolutionary history. The mitochondrial genome (mtDNA) is …